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Goto, Jun-Ichi; Fujii, Satoshi; Fujiwara, Hiroki; Mikoshiba, Katsuhiko; Yamazaki, Yoshihiko – Learning & Memory, 2022
In hippocampal CA1 neurons of wild-type mice, a short tetanus (15 or 20 pulses at 100 Hz) or a standard tetanus (100 pulses at 100 Hz) to a naive input pathway induces long-term potentiation (LTP) of the responses. Low-frequency stimulation (LFS; 1000 pulses at 1 Hz) 60 min after the standard tetanus reverses LTP (depotentiation [DP]), while LFS…
Descriptors: Animals, Brain Hemisphere Functions, Stimuli, Neurology
Sayegh, Fares; Herraiz, Laurie; Colom, Morgane; Lopez, Sébastien; Rampon, Claire; Dahan, Lionel – Learning & Memory, 2022
Dopamine participates in encoding memories and could either encode rewarding/aversive value of unconditioned stimuli or act as a novelty signal triggering contextual learning. Here we show that intraperitoneal injection of the dopamine D1/5R antagonist SCH23390 impairs contextual fear conditioning and tone-shock association, while intrahippocampal…
Descriptors: Cognitive Processes, Memory, Fear, Conditioning
Jin, Iksung; Kassabov, Stefan; Kandel, Eric R.; Hawkins, Robert D. – Learning & Memory, 2021
Most studies of molecular mechanisms of synaptic plasticity have focused on the sequence of changes either at individual synapses or in the cell nucleus. However, studies of long-term facilitation at "Aplysia" sensory neuron--motor neuron synapses in isolated cell culture suggest two additional features of facilitation. First, that there…
Descriptors: Animals, Neurological Organization, Molecular Structure, Physiology
Yokose, Jun; Marks, William D.; Yamamoto, Naoki; Ogawa, Sachie K.; Kitamura, Takashi – Learning & Memory, 2021
Temporal association learning (TAL) allows for the linkage of distinct, nonsynchronous events across a period of time. This function is driven by neural interactions in the entorhinal cortical-hippocampal network, especially the neural input from the pyramidal cells in layer III of medial entorhinal cortex (MECIII) to hippocampal CA1 is crucial…
Descriptors: Associative Learning, Brain Hemisphere Functions, Neurological Organization, Stimuli
Briggs, Sherri B.; Hannapel, Reilly; Ramesh, Janavi; Parent, Marise B. – Learning & Memory, 2021
Research into the neural mechanisms that underlie higher-order cognitive control of eating behavior suggests that ventral hippocampal (vHC) neurons, which are critical for emotional memory, also inhibit energy intake. We showed previously that optogenetically inhibiting vHC glutamatergic neurons during the early postprandial period, when the…
Descriptors: Neurological Organization, Brain Hemisphere Functions, Inhibition, Energy
Fujii, Satoshi; Yamazaki, Yoshihiko; Goto, Jun-ichi; Fujiwara, Hiroki; Mikoshiba, Katsuhiko – Learning & Memory, 2020
In CA1 neurons of guinea pig hippocampal slices, long-term potentiation (LTP) was induced in field excitatory postsynaptic potentials (EPSPs) or population spikes (PSs) by the delivery of high-frequency stimulation (HFS, 100 pulses at 100 Hz) to CA1 synapses, and was reversed by the delivery of a train of low-frequency stimulation (LFS, 1000…
Descriptors: Brain, Animals, Brain Hemisphere Functions, Stimuli
Costa, Renan M.; Baxter, Douglas A.; Byrne, John H. – Learning & Memory, 2020
Operant reward learning of feeding behavior in "Aplysia" increases the frequency and regularity of biting, as well as biases buccal motor patterns (BMPs) toward ingestion-like BMPs (iBMPs). The engram underlying this memory comprises cells that are part of a central pattern generating (CPG) circuit and includes increases in the intrinsic…
Descriptors: Memory, Brain Hemisphere Functions, Neurological Organization, Operant Conditioning
Gobin, Christina; Wu, Lizhen; Schwendt, Marek – Learning & Memory, 2020
The delayed match-to-sample task (DMS) is used to probe working memory (WM) across species. While the involvement of the PFC in this task has been established, limited information exists regarding the recruitment of broader circuitry, especially under the low- versus high-WM load. We sought to address this question by using a variable-delay…
Descriptors: Animals, Short Term Memory, Brain Hemisphere Functions, Training
Dolleman-van der Weel, Margriet J.; Griffin, Amy L.; Ito, Hiroshi T.; Shapiro, Matthew L.; Witter, Menno P.; Vertes, Robert P.; Allen, Timothy A. – Learning & Memory, 2019
The nucleus reuniens of the thalamus (RE) is a key component of an extensive network of hippocampal and cortical structures and is a fundamental substrate for cognition. A common misconception is that RE is a simple relay structure. Instead, a better conceptualization is that RE is a critical component of a canonical higher-order…
Descriptors: Brain Hemisphere Functions, Neurological Impairments, Anatomy, Physiology
Baram, Tallie Z.; Donato, Flavio; Holmes, Gregory L. – Learning & Memory, 2019
Spatial memory, the aspect of memory involving encoding and retrieval of information regarding one's environment and spatial orientation, is a complex biological function incorporating multiple neuronal networks. Hippocampus-dependent spatial memory is not innate and emerges during development in both humans and rodents. In children,…
Descriptors: Memory, Spatial Ability, Cognitive Processes, Neurological Organization
Fujii, Satoshi; Yamazaki, Yoshihiko; Goto, Jun-Ichi; Fujiwara, Hiroki; Mikoshiba, Katsuhiko – Learning & Memory, 2016
We investigated the role of inositol 1,4,5-trisphosphate receptors (IP3Rs) activated by preconditioning low-frequency afferent stimulation (LFS) in the subsequent induction of long-term potentiation (LTP) in CA1 neurons in hippocampal slices from mature guinea pigs. Induction of LTP in the field excitatory postsynaptic potential or the population…
Descriptors: Conditioning, Stimulation, Neurological Organization, Brain Hemisphere Functions
Hepp, Yanil; Salles, Angeles; Carbo-Tano, Martin; Pedreira, Maria Eugenia; Freudenthal, Ramiro – Learning & Memory, 2016
The aim of the present study was to analyze the surface expression of the NMDA-like receptors during the consolidation of contextual learning in the crab "Neohelice granulata". Memory storage is based on alterations in the strength of synaptic connections between neurons. The glutamatergic synapses undergo various forms of…
Descriptors: Animals, Memory, Brain Hemisphere Functions, Learning Processes
Davies, Don A.; Greba, Quentin; Selk, Jantz C.; Catton, Jillian K.; Baillie, Landon D.; Mulligan, Sean J.; Howland, John G. – Learning & Memory, 2017
Working memory is involved in the maintenance and manipulation of information essential for complex cognition. While the neural substrates underlying working memory capacity have been studied in humans, considerably less is known about the circuitry mediating working memory capacity in rodents. Therefore, the present experiments tested the…
Descriptors: Short Term Memory, Animals, Cognitive Processes, Neurological Organization
Kim, Seonil; Pick, Joseph E.; Abera, Sinedu; Khatri, Latika; Ferreira, Danielle D. P.; Sathler, Matheus F.; Morison, Sage L.; Hofmann, Franz; Ziff, Edward B. – Learning & Memory, 2016
Phosphorylation of GluA1, a subunit of AMPA receptors (AMPARs), is critical for AMPAR synaptic trafficking and control of synaptic transmission. cGMP-dependent protein kinase II (cGKII) mediates this phosphorylation, and cGKII knockout (KO) affects GluA1 phosphorylation and alters animal behavior. Notably, GluA1 phosphorylation in the KO…
Descriptors: Animals, Animal Behavior, Research, Memory
Davies, Don A.; Hurtubise, Jessica L.; Greba, Quentin; Howland, John G. – Learning & Memory, 2017
The trial-unique, delayed nonmatching-to-location (TUNL) task is a recently developed behavioral task that measures spatial working memory and a form of pattern separation in touchscreen-equipped operant conditioning chambers. Limited information exists regarding the neurotransmitters and neural substrates involved in the task. The present…
Descriptors: Brain Hemisphere Functions, Brain, Short Term Memory, Neurological Organization