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Direct linkStark, Shauna M.; Yassa, Michael A.; Stark, Craig E. L. – Learning & Memory, 2010
Rodent studies have suggested that "pattern separation," the ability to distinguish among similar experiences, is diminished in a subset of aged rats. We extended these findings to the human using a task designed to assess spatial pattern separation behavior (determining at time of test whether pairs of pictures shown during the study were in the…
Descriptors: Animals, Standardized Tests, Older Adults, Program Effectiveness
Verduzco, Luis; van Dyck, Christopher H.; Arnsten, Amy F. T.; Ramos, Brian P.; Stark, David – Learning & Memory, 2006
The working-memory functions of the prefrontal cortex (PFC) are improved by stimulation of postsynaptic, [alpha]2A-adrenoceptors, especially in aged animals with PFC cognitive deficits. Thus, the [alpha]2A-adrenoceptor agonist, guanfacine, greatly improves working-memory performance in monkeys and rats following systemic administration or…
Descriptors: Behavioral Science Research, Memory, Stimulation, Program Effectiveness
