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Novitskaya, Yulia; Sara, Susan J.; Logothetis, Nikos K.; Eschenko, Oxana – Learning & Memory, 2016
Experience-induced replay of neuronal ensembles occurs during hippocampal high-frequency oscillations, or ripples. Post-learning increase in ripple rate is predictive of memory recall, while ripple disruption impairs learning. Ripples may thus present a fundamental component of a neurophysiological mechanism of memory consolidation. In addition to…
Descriptors: Brain Hemisphere Functions, Memory, Recall (Psychology), Interference (Learning)
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Reichelt, Amy C.; Morris, Margaret J.; Westbrook, Reginald Frederick – Learning & Memory, 2016
High sugar diets reduce hippocampal neurogenesis, which is required for minimizing interference between memories, a process that involves "pattern separation." We provided rats with 2 h daily access to a sucrose solution for 28 d and assessed their performance on a spatial memory task. Sucrose consuming rats discriminated between objects…
Descriptors: Animals, Spatial Ability, Control Groups, Memory
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Johnson, Sarah A.; Sacks, Patricia K.; Turner, Sean M.; Gaynor, Leslie S.; Ormerod, Brandi K.; Maurer, Andrew P.; Bizon, Jennifer L.; Burke, Sara N. – Learning & Memory, 2016
Hippocampal-dependent episodic memory and stimulus discrimination abilities are both compromised in the elderly. The reduced capacity to discriminate between similar stimuli likely contributes to multiple aspects of age-related cognitive impairment; however, the association of these behaviors within individuals has never been examined in an animal…
Descriptors: Brain Hemisphere Functions, Animals, Models, Tests