Peer reviewed
Direct linkERIC Number: EJ767992
Record Type: Journal
Publication Date: 2006
Pages: 4
Abstractor: Author
ISBN: N/A
ISSN: ISSN-1072-0502
EISSN: N/A
Available Date: N/A
Two Mutations Preventing PDZ-Protein Interactions of GluR1 Have Opposite Effects on Synaptic Plasticity
Boehm, Jannic; Ehrlich, Ingrid; Hsieh, Helen; Malinow, Roberto
Learning & Memory, v13 n5 p562-565 Sep-Oct 2006
The regulated trafficking of GluR1 contributes significantly to synaptic plasticity, but studies addressing the function of the GluR1 C-terminal PDZ-ligand domain in this process have produced conflicting results. Here, we resolve this conflict by showing that apparently similar C-terminal mutations of the GluR1 PDZ-ligand domain result in opposite physiological phenotypes during activity- and CamKII-induced synaptic plasticity.
Descriptors: Cytology, Biological Influences, Physiology, Convergent Thinking, Inhibition, Conditioning, Scientific Research, Scientific Methodology, Structural Analysis (Science), Molecular Biology, Genetics
Cold Spring Harbor Laboratory Press. 500 Sunnyside Boulevard, Woodbury, NY 11797-2924. Tel: 800-843-4388; 516-367-8800; Fax: 516-422-4097; e-mail: cshpres@cshl.edu; Web site: http://www.learnmem.org/
Publication Type: Journal Articles; Reports - Evaluative
Education Level: N/A
Audience: N/A
Language: English
Sponsor: N/A
Authoring Institution: N/A
Grant or Contract Numbers: N/A
Author Affiliations: N/A
