In behavioral research, interest is often in examining the degree to which the effect of an independent variable X on an outcome Y is mediated by an intermediary or mediator variable M. This article illustrates how generalized estimating equations (GEE) modeling can be used to estimate the indirect or mediated effect, defined as the amount by…

In studies of relatives, conventional multiple regression may not be appropriate because observations are not independent. Obtaining estimates of regression coefficients and correct standard errors from these populations through a structural equation modeling framework is discussed and illustrated with data from twins. (SLD)