Incomplete or missing data is a common problem in almost all areas of empirical research. It is well known that simple and ad hoc methods such as complete case analysis or mean imputation can lead to biased and/or inefficient estimates. The method of maximum likelihood works well; however, when the missing data mechanism is not one of missing…

In studies of relatives, conventional multiple regression may not be appropriate because observations are not independent. Obtaining estimates of regression coefficients and correct standard errors from these populations through a structural equation modeling framework is discussed and illustrated with data from twins. (SLD)