This paper illustrates an application of Efron's bootstrap to the repeated measures design. While this approach does not require parametric assumptions, it does utilize distributional information in the sample. By appropriately resampling from study data, the bootstrap may determine accurate sampling distributions for estimators, effects, or…

The utility of the three-form design coupled with maximum likelihood methods for estimation of missing values was evaluated. Simulation studies demonstrate that maximum likelihood estimation and multiple imputation methods produce the most efficient and least biased estimates of variances and covariances for normally distributed and slightly…