The purpose of this is study is to reveal how the anxiety that the teachers who work in the Beyoglu district of Istanbul experience, due to the supervision process, predict their organizational cynicism levels. With this respect, the study was conducted on 274 teachers with the relational screening model. The "Supervision Anxiety Scale" and the "Organizational Cynicism Scale" were used to collect the data. The SPSS 22.0 software was used to analyze the data and arithmetic mean, standard deviation, Pearson Product-Moment Correlation Analysis and regression analyses were conducted. According to the study findings, there is a positive, moderate level and statistically significant level relationship between supervision anxiety and organizational cynicism levels of teachers. The regression analysis results suggest that supervision anxiety of teachers is a significant predictor of their organizational cynicism levels.