Teaching materials development in Islamic universities is oriented to the concept of scientific integration which is expected to contribute positively to the development and study of Islam. This study aims to develop valid, practical and effective Indonesian language teaching materials at the Institut Agama Islam Negeri (IAIN) Palopo. This research is a research and development (Research and Development) using the Borg & Gall model involving 117 students, 6 Indonesian lecturers, and 2 Indonesian language learning experts. The research instrument is questionnaire validation of teaching materials which included aspects of material, presentation, graphic and language, observation sheet of practicality of teaching materials, and student achievement test. This study produced a textbook with the title "Indonesian Language for Islamic Universities". This book was developed based on the needs of students and lecturers at IAIN Palopo. Based on the analysis results, the validity of this textbook is in the category of very valid. The quality of this textbook is equivalent to the results of the learning implementation. The response of students and lecturers, observations of the implementation of learning and student learning outcomes showed positive results. This is supported by quantitative data obtained from the results of descriptive and inferential statistical analysis.