Most of the world's languages include multiple varieties and dialects. Individual ability to successfully alternate between these varieties can be a socio-cultural and academic necessity for many bilingual speakers, including children in the US who alternate between African American English (AAE) and Mainstream American English (MAE). This…

Reading is a complex task that requires integration of information across brain systems that support sensory, language and cognitive processing. Individuals vary widely in reading ability: some read almost effortlessly, while others struggle to make sense of printed text. Factors at multiple levels from genes and brain through environment…

With the rise of bilinguals globally, extensive research has been conducted to understand how bilingualism affects cognitive functions differently from monolingualism, with significant implications for bilingual education, healthcare, and other fields. Specific to language processing, differences have been identified between second language (L2)…

The problem addressed by this study was the commonly held belief that lack of confidence, preparedness, educational neuromyths, and little or no professional development are factors that impede early childhood teachers' implementation of brain-based learning strategies in the daily curriculum design structure. This qualitative narrative inquiry…

Early childhood language experiences influence how a child's mind and brain process language and acquire literacy. For children growing up bilingual, their two languages interact in their minds, and these cross-linguistic influences can lead to unique neurocognitive mechanisms for language and reading compared to monolinguals. In this…

Clear speech is a speaking style that has been shown to improve intelligibility in adverse listening conditions, for various listener and talker populations. Clear-speech phonetic enhancements include a slowed speech rate, expanded vowel space, and expanded pitch range. Although clear-speech phonetic enhancements have been demonstrated across a…

This project used Event-Related Potentials (ERPs) to explore neurophysiological brain responses to prepositional phrases involving concrete and abstract reference nouns (e.g., "plate" and "moment," respectively) after the presentation of objects with varying spatial features. Prepositional phrases were headed by "in"…

Communication, specifically the elements crucial for normal social interaction, can be significantly affected in psychiatric illness, especially depression. Of specific importance are prosody (an aspect of speech that carries emotional valence) and formulaic language (non-novel linguistic segments that are prevalent in naturalistic conversation).…

Intercellular signaling is vital to communication within neuronal circuits. The suprachiasmatic nucleus (SCN), the master circadian clock of mammals, contains a dense collection of neurons that align their intrinsic rhythmicity with environmental stimulus and physiological state. While peptide physiology has been demonstrated as a contributor to…

The field of research in bilingualism and second language (L2) acquisition has yielded overwhelming evidence that acquiring a second language later in life will result in less accurate production and perception of consonants and vowels in the second language. These effects, in part, are a result of interference from the already formed phonetic…

The scope, breadth, and volume of data characterizing our current understanding of how the brain functions is growing at an increasingly rapid pace. What is more, theories are becoming increasing complex and nuanced, integrating knowledge from multiple previously independent sources of scientific inquiry. The research described within this…

This dissertation contains several projects, each addressing different questions with different techniques. In chapter 1, I argue that they are unified thematically by their goal of "scaling up psycholinguistics"; they are all aimed at analyzing large data-sets using tools that reveal patterns to propose and test mechanism-neutral hypotheses about…

Short term synaptic plasticity is a phenomenon which is commonly found in the central nervous system. It could contribute to functions of signal processing namely, temporal integration and coincidence detection by modulating the input synaptic strength. This dissertation has two parts. First, we study the effects of short term synaptic plasticity…

Understanding the functioning of the brain is hindered by a lack of knowledge of the full complement of neurotransmitters and neuromodulatory compounds. Single cell measurements aid in the discovery of neurotransmitters used by small subsets of neurons that would be diluted below detection limits or masked by ubiquitous compounds when working with…

It has long been appreciated that adequate nutrition is required for proper immune function and it is now recognized that dietary components contribute to modulation of immune cells, subsequently impacting the whole body's response during an immune challenge. Macrophage activation plays a critical role in the immune system and directs the…