Background: Neonatal abstinence syndrome (NAS) is on the rise in the United States. Opioid-use disorder has increased among the population of women of childbearing age. Over the past two decades, the increased rate of opioid-use disorder has caused a five-fold increase in NAS. NAS affects three out of four babies who are exposed to chronic use of opioids during the mother's pregnancy. Caring for infants with NAS is challenging. At the same time, researchers have identified a deficit of knowledge and skills as well as judgmental attitude of nurses caring for babies with NAS. Nationwide, nurses need education on current evidence-based practice to change knowledge and attitudes and to improve quality of care of infants with NAS. Methods: This quality improvement project used the design thinking process to assess the local needs of nurses at a non-profit hospital setting and subsequently develop education to address care for infants experiencing NAS. All nurses caring for infants with NAS in a neonatal intensive care unit were invited to participate. A pre-survey of the nurses' knowledge and attitudes was conducted to obtain baseline data. Then, nurses were interviewed until a level of saturation regarding their educational needs (both knowledge and attitude) was reached. Educational materials were prototyped in subsequent interviews scheduled with the neonatal nurses until the materials were found useful. Intervention: The purpose of this project was to assess the educational needs for staff nurses from the NICU working with babies experiencing NAS and to use the design thinking process to create an educational intervention to meet the nurses' needs. Analysis: Nurses baseline attitudes and knowledge were described. Interviews identified local needs. Themes from the interviews were analyzed using content analysis methods. Findings: This project was undertaken in partial fulfillment of the Doctorate of Nursing Practice. [The dissertation citations contained here are published with the permission of ProQuest LLC. Further reproduction is prohibited without permission. Copies of dissertations may be obtained by Telephone (800) 1-800-521-0600. Web page: http://www.proquest.com/en-US/products/dissertations/individuals.shtml.]