Network meta-analysis has been an essential methodology of systematic reviews for comparative effectiveness research. The restricted maximum likelihood (REML) method is one of the current standard inference methods for multivariate, contrast-based meta-analysis models, but recent studies have revealed the resultant confidence intervals of average…

Assessing publication bias is a critical procedure in meta-analyses for rating the synthesized overall evidence. Because statistical tests for publication bias are usually not powerful and only give "P" values that inform either the presence or absence of the bias, examining the asymmetry of funnel plots has been popular to investigate…

Systematic reviewers conducting pairwise meta-analyses sometimes encounter multi-arm studies. To include these studies, and to avoid a unit-of-analysis error, often two or more arms are combined or the control arm is split. In this tutorial, we present 5 different approaches that can be used. Particularly, we present a novel approach (method 4)…