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Lu Qin; Shishun Zhao; Wenlai Guo; Tiejun Tong; Ke Yang – Research Synthesis Methods, 2024
The application of network meta-analysis is becoming increasingly widespread, and for a successful implementation, it requires that the direct comparison result and the indirect comparison result should be consistent. Because of this, a proper detection of inconsistency is often a key issue in network meta-analysis as whether the results can be…
Descriptors: Meta Analysis, Network Analysis, Bayesian Statistics, Comparative Analysis
Seo, Michael; Furukawa, Toshi A.; Veroniki, Areti Angeliki; Pillinger, Toby; Tomlinson, Anneka; Salanti, Georgia; Cipriani, Andrea; Efthimiou, Orestis – Research Synthesis Methods, 2021
Network meta-analysis (NMA) can be used to compare multiple competing treatments for the same disease. In practice, usually a range of outcomes is of interest. As the number of outcomes increases, summarizing results from multiple NMAs becomes a nontrivial task, especially for larger networks. Moreover, NMAs provide results in terms of relative…
Descriptors: Networks, Network Analysis, Meta Analysis, Visualization
Bennetts, Meg; Whalen, Ed; Ahadieh, Sima; Cappelleri, Joseph C. – Research Synthesis Methods, 2017
Although well developed to assess efficacy questions, meta-analyses and, more generally, systematic reviews, have received less attention in application to safety-related questions. As a result, many open questions remain on how best to apply meta-analyses in the safety setting. This appraisal attempts to: (i) summarize the current guidelines for…
Descriptors: Meta Analysis, Guidelines, Network Analysis, Safety
Freeman, S. C.; Fisher, D.; Tierney, J. F.; Carpenter, J. R. – Research Synthesis Methods, 2018
Background: Stratified medicine seeks to identify patients most likely to respond to treatment. Individual participant data (IPD) network meta-analysis (NMA) models have greater power than individual trials to identify treatment-covariate interactions (TCIs). Treatment-covariate interactions contain "within" and "across" trial…
Descriptors: Medical Research, Patients, Outcomes of Treatment, Meta Analysis
Shadish, William R.; Lecy, Jesse D. – Research Synthesis Methods, 2015
This article looks at the impact of meta-analysis and then explores why meta-analysis was developed at the time and by the scholars it did in the social sciences in the 1970s. For the first problem, impact, it examines the impact of meta-analysis using citation network analysis. The impact is seen in the sciences, arts and humanities, and on such…
Descriptors: Meta Analysis, Research Methodology, Social Science Research, Citations (References)