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Direct linkKylie E. Hunter; Mason Aberoumand; Sol Libesman; James X. Sotiropoulos; Jonathan G. Williams; Jannik Aagerup; Rui Wang; Ben W. Mol; Wentao Li; Angie Barba; Nipun Shrestha; Angela C. Webster; Anna Lene Seidler – Research Synthesis Methods, 2024
Increasing concerns about the trustworthiness of research have prompted calls to scrutinise studies' Individual Participant Data (IPD), but guidance on how to do this was lacking. To address this, we developed the IPD Integrity Tool to screen randomised controlled trials (RCTs) for integrity issues. Development of the tool involved a literature…
Descriptors: Integrity, Randomized Controlled Trials, Participant Characteristics, Computer Software
Yuan Tian; Xi Yang; Suhail A. Doi; Luis Furuya-Kanamori; Lifeng Lin; Joey S. W. Kwong; Chang Xu – Research Synthesis Methods, 2024
RobotReviewer is a tool for automatically assessing the risk of bias in randomized controlled trials, but there is limited evidence of its reliability. We evaluated the agreement between RobotReviewer and humans regarding the risk of bias assessment based on 1955 randomized controlled trials. The risk of bias in these trials was assessed via two…
Descriptors: Risk, Randomized Controlled Trials, Classification, Robotics
Su, Yu-Xuan; Tu, Yu-Kang – Research Synthesis Methods, 2018
Network meta-analysis compares multiple treatments in terms of their efficacy and harm by including evidence from randomized controlled trials. Most clinical trials use parallel design, where patients are randomly allocated to different treatments and receive only 1 treatment. However, some trials use within person designs such as split-body,…
Descriptors: Network Analysis, Meta Analysis, Randomized Controlled Trials, Research Design
Armijo-Olivo, Susan; Craig, Rodger; Campbell, Sandy – Research Synthesis Methods, 2020
Background: Evidence from new health technologies is growing, along with demands for evidence to inform policy decisions, creating challenges in completing health technology assessments (HTAs)/systematic reviews (SRs) in a timely manner. Software can decrease the time and burden by automating the process, but evidence validating such software is…
Descriptors: Comparative Analysis, Computer Software, Decision Making, Randomized Controlled Trials
Marshall, Iain J.; Noel-Storr, Anna; Kuiper, Joël; Thomas, James; Wallace, Byron C. – Research Synthesis Methods, 2018
Machine learning (ML) algorithms have proven highly accurate for identifying Randomized Controlled Trials (RCTs) but are not used much in practice, in part because the best way to make use of the technology in a typical workflow is unclear. In this work, we evaluate ML models for RCT classification (support vector machines, convolutional neural…
Descriptors: Randomized Controlled Trials, Accuracy, Computer Software, Classification
Debray, Thomas P. A.; Moons, Karel G. M.; van Valkenhoef, Gert; Efthimiou, Orestis; Hummel, Noemi; Groenwold, Rolf H. H.; Reitsma, Johannes B. – Research Synthesis Methods, 2015
Individual participant data (IPD) meta-analysis is an increasingly used approach for synthesizing and investigating treatment effect estimates. Over the past few years, numerous methods for conducting an IPD meta-analysis (IPD-MA) have been proposed, often making different assumptions and modeling choices while addressing a similar research…
Descriptors: Meta Analysis, Outcomes of Treatment, Research Methodology, Literature Reviews
