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Ferdinand Valentin Stoye; Claudia Tschammler; Oliver Kuss; Annika Hoyer – Research Synthesis Methods, 2024
The development of new statistical models for the meta-analysis of diagnostic test accuracy studies is still an ongoing field of research, especially with respect to summary receiver operating characteristic (ROC) curves. In the recently published updated version of the "Cochrane Handbook for Systematic Reviews of Diagnostic Test…
Descriptors: Diagnostic Tests, Accuracy, Barriers, Models
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Riley, Richard D.; Collins, Gary S.; Hattle, Miriam; Whittle, Rebecca; Ensor, Joie – Research Synthesis Methods, 2023
Before embarking on an individual participant data meta-analysis (IPDMA) project, researchers should consider the power of their planned IPDMA conditional on the studies promising their IPD and their characteristics. Such power estimates help inform whether the IPDMA project is worth the time and funding investment, before IPD are collected. Here,…
Descriptors: Computation, Meta Analysis, Participant Characteristics, Data
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Wang, Wei-Jhih; Devine, Beth; Bansal, Aasthaa; White, H. Steve; Basu, Anirban – Research Synthesis Methods, 2021
Meta-analyzing count data can be challenging when follow-up time varies across studies. Simply pooling aggregate data over time-periods would result in biased estimates, which may erroneously inform clinical decision-making. In this study, we exploit the convolution property of the Poisson distribution to develop a likelihood for observed…
Descriptors: Meta Analysis, Data, Statistical Distributions, Computation
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Hoyer, Annika; Kuss, Oliver – Research Synthesis Methods, 2020
Diagnostic accuracy studies often evaluate diagnostic tests at several threshold values, aiming to make recommendations on optimal thresholds for use in practice. Methods for meta-analysis of full receiver operating characteristic (ROC) curves have been proposed but still have deficiencies. We recently proposed a parametric approach that is based…
Descriptors: Diagnostic Tests, Research Methodology, Accuracy, Meta Analysis