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Direct linkFreeman, Suzanne C.; Carpenter, James R. – Research Synthesis Methods, 2017
Network meta-analysis (NMA) combines direct and indirect evidence from trials to calculate and rank treatment estimates. While modelling approaches for continuous and binary outcomes are relatively well developed, less work has been done with time-to-event outcomes. Such outcomes are usually analysed using Cox proportional hazard (PH) models.…
Descriptors: Bayesian Statistics, Network Analysis, Meta Analysis, Data
Leahy, Joy; O'Leary, Aisling; Afdhal, Nezam; Gray, Emma; Milligan, Scott; Wehmeyer, Malte H.; Walsh, Cathal – Research Synthesis Methods, 2018
The use of individual patient data (IPD) in network meta-analysis (NMA) is becoming increasingly popular. However, as most studies do not report IPD, most NMAs are performed using aggregate data for at least some, if not all, of the studies. We investigate the benefits of including varying proportions of IPD studies in an NMA. Several models have…
Descriptors: Patients, Medical Research, Meta Analysis, Network Analysis
