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Individual Participant Data Meta-Analysis of Intervention Studies with Time-to-Event Outcomes: A Review of the Methodology and an Applied Example
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de Jong, Valentijn M. T.; Moons, Karel G. M.; Riley, Richard D.; Tudur Smith, Catrin; Marson, Anthony G.; Eijkemans, Marinus J. C.; Debray, Thomas P. A. – Research Synthesis Methods, 2020
Many randomized trials evaluate an intervention effect on time-to-event outcomes. Individual participant data (IPD) from such trials can be obtained and combined in a so-called IPD meta-analysis (IPD-MA), to summarize the overall intervention effect. We performed a narrative literature review to provide an overview of methods for conducting an…
Descriptors: Meta Analysis, Intervention, Randomized Controlled Trials, Guidelines
Ten Questions to Consider When Interpreting Results of a Meta-Epidemiological Study--The MetaBLIND Study as a Case
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Moustgaard, Helene; Jones, Hayley E.; Savovic, Jelena; Clayton, Gemma L.; Sterne, Jonathan AC; Higgins, Julian PT; Hróbjartsson, Asbjørn – Research Synthesis Methods, 2020
Randomized clinical trials underpin evidence-based clinical practice, but flaws in their conduct may lead to biased estimates of intervention effects and hence invalid treatment recommendations. The main approach to the empirical study of bias is to collate a number of meta-analyses and, within each, compare the results of trials with and without…
Descriptors: Epidemiology, Evidence, Medical Research, Intervention