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Direct linkFranco, Juan Víctor Ariel; Garrote, Virginia Laura; Escobar Liquitay, Camila Micaela; Vietto, Valeria – Research Synthesis Methods, 2018
Objective: Search strategies are essential for the adequate retrieval of studies in a systematic review (SR). Our objective was to identify problems in the design and reporting of search strategies in a sample of new Cochrane SRs first published in The Cochrane Library in 2015. Study design and setting: We took a random sample of 70 new Cochrane…
Descriptors: Search Strategies, Literature Reviews, Online Searching, Intervention
Moustgaard, Helene; Jones, Hayley E.; Savovic, Jelena; Clayton, Gemma L.; Sterne, Jonathan AC; Higgins, Julian PT; Hróbjartsson, Asbjørn – Research Synthesis Methods, 2020
Randomized clinical trials underpin evidence-based clinical practice, but flaws in their conduct may lead to biased estimates of intervention effects and hence invalid treatment recommendations. The main approach to the empirical study of bias is to collate a number of meta-analyses and, within each, compare the results of trials with and without…
Descriptors: Epidemiology, Evidence, Medical Research, Intervention
Freeman, S. C.; Fisher, D.; Tierney, J. F.; Carpenter, J. R. – Research Synthesis Methods, 2018
Background: Stratified medicine seeks to identify patients most likely to respond to treatment. Individual participant data (IPD) network meta-analysis (NMA) models have greater power than individual trials to identify treatment-covariate interactions (TCIs). Treatment-covariate interactions contain "within" and "across" trial…
Descriptors: Medical Research, Patients, Outcomes of Treatment, Meta Analysis
Wells, George A.; Shea, Beverley; Higgins, Julian P. T.; Sterne, Jonathan; Tugwell, Peter; Reeves, Barnaby C. – Research Synthesis Methods, 2013
Background: There is increasing interest from review authors about including non-randomized studies (NRS) in their systematic reviews of health care interventions. This series from the Ottawa Non-Randomized Studies Workshop consists of six papers identifying methodological issues when doing this. Aim: To format the guidance from the preceding…
Descriptors: Health Services, Intervention, Workshops, Research Methodology
