Network meta-analysis (NMA) is a statistical technique for the comparison of treatment options. Outcomes of Bayesian NMA include estimates of treatment effects, and the probabilities that each treatment is ranked best, second best and so on. How exactly network topology affects the accuracy and precision of these outcomes is not fully understood.…

The accuracy of a diagnostic test is often expressed using a pair of measures: sensitivity (proportion of test positives among all individuals with target condition) and specificity (proportion of test negatives among all individuals without target condition). If the outcome of a diagnostic test is binary, results from different studies can easily…

For estimation of heterogeneity variance T[superscript 2] in meta-analysis of log-odds-ratio, we derive new mean- and median-unbiased point estimators and new interval estimators based on a generalized Q statistic, Q[subscript F], in which the weights depend on only the studies' effective sample sizes. We compare them with familiar estimators…

Population adjustment methods such as matching-adjusted indirect comparison (MAIC) are increasingly used to compare marginal treatment effects when there are cross-trial differences in effect modifiers and limited patient-level data. MAIC is based on propensity score weighting, which is sensitive to poor covariate overlap and cannot extrapolate…

The use of individual patient data (IPD) in network meta-analysis (NMA) is becoming increasingly popular. However, as most studies do not report IPD, most NMAs are performed using aggregate data for at least some, if not all, of the studies. We investigate the benefits of including varying proportions of IPD studies in an NMA. Several models have…