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Huiskens, Joost; Kool, Boudewijn R. J.; Bakker, Jean-Michel; Bruns, Emma R. J.; de Jonge, Stijn W.; Olthof, Pim B.; van Rosmalen, Belle V.; van Gulik, Thomas M.; Hooft, Lotty; Punt, Cornelis J. A. – Research Synthesis Methods, 2020
Introduction: Registration of clinical trials has been initiated in order to assess adherence of the reported results to the original trial protocol. This study aimed to investigate the publication rates, timely dissemination of results, and the prevalence of consistency in hypothesis, sample size, and primary endpoint of Dutch…
Descriptors: Randomized Controlled Trials, Databases, Foreign Countries, Medical Research
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Moustgaard, Helene; Jones, Hayley E.; Savovic, Jelena; Clayton, Gemma L.; Sterne, Jonathan AC; Higgins, Julian PT; Hróbjartsson, Asbjørn – Research Synthesis Methods, 2020
Randomized clinical trials underpin evidence-based clinical practice, but flaws in their conduct may lead to biased estimates of intervention effects and hence invalid treatment recommendations. The main approach to the empirical study of bias is to collate a number of meta-analyses and, within each, compare the results of trials with and without…
Descriptors: Epidemiology, Evidence, Medical Research, Intervention
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Biocic, Marina; Fidahic, Mahir; Cikes, Karla; Puljak, Livia – Research Synthesis Methods, 2019
Background: It has been reported that information sources searched in systematic reviews (SRs) are insufficiently comprehensive. We analyzed information sources used in SRs, as well as how up-to-date were the searches. Methods: We searched PubMed and the Cochrane Database of Systematic Reviews (CDSR) through Wiley from 2012 to 2016 to find SRs of…
Descriptors: Pain, Case Studies, Anesthesiology, Databases
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Norris, Susan L.; Moher, David; Reeves, Barnaby C.; Shea, Beverley; Loke, Yoon; Garner, Sarah; Anderson, Laurie; Tugwell, Peter; Wells, George – Research Synthesis Methods, 2013
Background: Selective outcome and analysis reporting (SOR and SAR) occur when only a subset of outcomes measured and analyzed in a study is fully reported, and are an important source of potential bias. Key methodological issues: We describe what is known about the prevalence and effects of SOR and SAR in both randomized controlled trials (RCTs)…
Descriptors: Health Services, Intervention, Outcomes of Treatment, Research Methodology