Theoretical model suggests antigen-sensitive cells produce antibodies only when two antigenic determinants are recognized, and explains self-nonself discrimination by antibody system. Specific antigen-sensitive cells accumulate in absence of foreign antigens and co-operate to induce antibodies if antigen enter the body; but antigen-sensitive cells…

Describes research on synergistic effects of alcohol and other drugs, particularly barbiturates. Proposes biochemical mechanisms to explain alcoholics' tolerance of other drugs when sober, and increased sensitivity when drunk. (AL)

Traces the history of the molecular approach to biology from the late 19th century. Describes the development of investigatory techniques as well as of knowledge of molecular structure. (EB)

Proposes a molecular mechanism for the coupling of phosphorylation to electron transport in both mitochondria and chloroplasts. Justifies the proposed reaction schemes in terms of thermodynamics and biochemical data. Suggests how areobic respiration could have evolved. (EB)

Discussed is the discovery which may help to explain epidermal growth factor effects on the cell skeleton. The role of a protein called profilin in the regulation of the microfilament system is described. (CW)

The concentration of the primary brain metabolite of norepinephrine is diminished in the lumbar spinal fluid of patients with Korsakoff's syndrome. The extent of its reduction is correlated with measures of memory impairment. (BB)

Presents a hypothesis about the biochemical processes involved in memory storage. The postulated mechanism is initiated by a signal that is unusual but not unlikely to occur and produces an irreversible change in a key component of synaptic chemistry. Other features of the mechanism and experiments supporting the hypothesis are considered. (JN)

Advances in the genetics and cell biology of muscle development are discussed. In-vitro analysis of the renaturation, polymerization, and three-dimensional structure of the purified proteins involved is described. (CW)

Describes 16 mutagens/carcinogens found in plant food and coffee as well as several anticarcinogens also found in such food. Speculates on relevant biochemical mechanisms, particularly the role of oxygen radicals and their inhibitors in the fat/cancer relationship, promotion, anticarcinogenesis, and aging. (JN)