Encouraging students' interest in science has never been more important. Science plays a greater role in everyones lives than ever before, and students who have a solid foundation in science are prepared to pursue a wide range of opportunities in high school, college, and the workplace. Yet many students--particularly girls and students from diverse cultural backgrounds--are leaving school without the confidence or preparation they need in science. Research shows that boys and girls start out their education with equal interest and aptitude in science. However, by about sixth grade, more girls than boys begin to turn away from science--even though they still have the aptitude for the subject. The reasons for this are subtle and rooted in cultural stereotypes. These stereotypes are changing, but still influence how students view science and their relationship to it. This article discusses Sally Ride Science, a company dedicated to empowering girls to explore the world of science--from astrobiology to zoology.