Universal Design for Learning (UDL) provides a framework, based in brain research, to design instruction around the needs of all learners. By considering the UDL principles as educators design science instruction, they can proactively address how to engage students, how to make content accessible, and how to provide options for students to demonstrate learning. The authors provide a visual representation of the UDL principles divided into guidelines, with specific checkpoints to guide instruction; a quick reference guide to the barriers to science instruction, corresponding UDL checkpoint, and strategies; and introduce hypothetical scenarios where teachers encounter the barriers and use UDL principles to find solutions.