This protocol guides the review of research that informs the What Works Clearinghouse (WWC) intervention reports in the postsecondary Career and Technical Education (CTE) topic area. The review-specific protocol is used in conjunction with the "WWC Procedures and Standards Handbook" (version 4.0). WWC reviews in this topic area focus on postsecondary CTE interventions that help students achieve technical skill proficiency and/or an industry-recognized credential, a certificate, a license, an associate degree, or in the longer term, a baccalaureate degree.