Prenatal maternal depression affects both mother and fetus with long-term implications for offspring vulnerability to psychopathology through alterations to brain development, stress physiology, negative emotionality, and cognitive control. This article reviews evidence for the negative impact of prenatal maternal depression on offspring…

Advances in understanding of the dynamic molecular interplay between DNA and its surrounding proteins suggest that epigenetic mechanisms are a critical link between early life experiences (e.g., prenatal stress, parent-offspring interactions) and long-term changes in brain and behavior. Although much of this evidence comes from animal studies,…

Too many parents who find themselves involved with child welfare agencies have had lives threaded with deeply traumatic events. As adults, their childhood histories manifest themselves in substance abuse, domestic violence, relational problems, risk-taking behaviors, emotional lability, self-harming, anxiety, and depression. To successfully…

There is good evidence that if a woman is depressed, anxious, or stressed while she is pregnant, then there is an increased risk that her child will have emotional, behavioral, or cognitive problems. Her own biology must cause these effects, but it is not known how. One important line of research suggests that the function of the placenta changes…

The recognition that adverse childhood experiences have long-term negative effects parallels the explosion of evidence demonstrating how early experience gets into the body and brain. This knowledge, in turn, has significant implications for treatment of emotional and behavioral problems in early childhood. In this article, I offer a guide to…

The fetal programming and developmental origins of disease models suggest that experiences that occur before birth can have consequences for physical and mental health that persist across the lifespan. Development is more rapid during the prenatal period as compared to any other stage of life. This introductory article considers evidence that…

Pregnancy anxiety is a particular emotional state tied to pregnancy-specific concerns, such as worries about the health of the baby and childbirth. A growing body of research demonstrates that pregnancy anxiety is an important risk factor for preterm birth and other adverse birth and child development outcomes. This article defines and describes…

Neuroscientists have long believed that there are sensitive periods in development during which the effects of experience play a critical role. And developmental psychologists have argued for the importance of early experience in the first years of life as being critical for brain and behavioral development. Most of the neuroscience research…

There have been revolutionary advances in the last decade in researcher's understanding of the genesis of life course health from the critical formative experiences before birth. Even more striking are the factors in a mother's developmental and nutritional history and experience that shape her health, a healthy pregnancy and delivery, and the…

Clinical research during the pregnancy period is maximally beneficial for participants if it is positive, inclusive, and therapeutic. We describe our ongoing study of ethnically diverse, low-income pregnant women and fathers-to-be that leverages participants' benevolent childhood experiences (BCEs) and promotes insight to counteract mental health…

This nine-unit curriculum translates current scientific research on early brain development into practical suggestions to help early childhood professionals understand the reciprocal link between caregiving and brain development. The curriculum was created and extensively field-tested by the Erikson Institute Faculty Development Project on the…