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Brief Report: Pilot Single-Blind Placebo Lead-in Study of Acamprosate in Youth with Autistic Disorder
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Erickson, Craig A.; Wink, Logan K.; Early, Maureen C.; Stiegelmeyer, Elizabeth; Mathieu-Frasier, Lauren; Patrick, Vanessa; McDougle, Christopher J. – Journal of Autism and Developmental Disorders, 2014
Rationale: An excitatory/inhibitory (E:I) imbalance marked by enhanced glutamate and deficient gamma-aminobutyric acid (GABA) neurotransmission may contribute to the pathophysiology of autism spectrum disorders (ASD). Objectives: We report on the first single-blind placebo lead-in trial of acamprosate, a drug with putative mechanisms restoring E:I…
Descriptors: Autism, Pervasive Developmental Disorders, Drug Therapy, Metabolism
Behavioral, Personality, and Communicative Predictors of Acceptance and Popularity in Early Adolescence
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Wolters, Nina; Knoors, Harry; Cillessen, Antonius H. N.; Verhoeven, Ludo – Journal of Early Adolescence, 2014
This study examined the behavioral, personality, and communicative predictors of acceptance and popularity in 608 early adolescents. Data were collected with sociometric methods and ratings in 30 sixth-grade classrooms. Hierarchical regressions were run to predict acceptance and popularity from prosocial, antisocial, and withdrawn behavior,…
Descriptors: Peer Acceptance, Antisocial Behavior, Role, Extraversion Introversion
Early Childhood Assessments of Community Pediatric Professionals Predict Autism Spectrum and Attention Deficit Hyperactivity Problems
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Jaspers, Merlijne; de Winter, Andrea F.; Buitelaar, Jan K.; Verhulst, Frank C.; Reijneveld, Sijmen A.; Hartman, Catharina A. – Journal of Abnormal Child Psychology, 2013
For clinically referred children with Autism Spectrum Disorder (ASD) or Attention Deficit/Hyperactivity Disorder (ADHD) several early indicators have been described. However, knowledge is lacking on early markers of less severe variants of ASD and ADHD from the general population. The aim of the present study is to identify early indicators of…
Descriptors: Pregnancy, Social Behavior, Attention Deficit Hyperactivity Disorder, Adolescents
Social Anxiety in High-Functioning Children and Adolescents with Autism and Asperger Syndrome
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Kuusikko, Sanna; Pollock-Wurman, Rachel; Jussila, Katja; Carter, Alice S.; Mattila, Marja-Leena; Ebeling, Hanna; Pauls, David L.; Moilanen, Irma – Journal of Autism and Developmental Disorders, 2008
We examined social anxiety and internalizing symptoms using the Social Phobia and Anxiety Inventory for Children (SPAI-C), the Social Anxiety Scale for Children -Revised (SASC-R), and the Child Behavior Checklist (CBCL) in a sample of fifty-four high-functioning subjects with autism or Asperger syndrome (HFA/AS) (M = 11.2 plus or minus 1.7 years)…
Descriptors: Check Lists, Autism, Asperger Syndrome, Child Behavior