Monitoring the Future (MTF) is an ongoing research program conducted at the University of Michigan's Institute for Social Research under a series of investigator-initiated research grants from the National Institute on Drug Abuse beginning in 1975. The integrated MTF study includes annual surveys of nationally-representative samples of 8th, 10th,…

Objective: This research examined why smokers receiving combination medication for smoking cessation are more likely to quit smoking than are those who receive either single agent (monotherapy) or placebo. Method: Data were collected from 1,504 current smokers (58.2% women, 83.9% White; mean age = 44.67 years, SD = 11.08) participating in a…

The effectiveness of fenfluramine with hyperserotonergic autistic individuals (n=28 and ages 6-30) was evaluated. Evaluation of videotape recordings of individual behaviors suggested that fenfluramine failed to increase communicative behaviors or decrease stereotypic behaviors and inappropriate behaviors although a serotonergic effect was found in…

Two studies investigated self-injurious behavior (SIB) in a man with profound disabilities. Results indicated that the rate of SIB varied depending on contextual conditions and behavioral state, and a treatment plan that involved manipulation of the environment depending on behavioral states and the use of Fluphenazine reduced SIB. (Author/ CR)

The opioid antagonist naltrexone was administered to eight adults with severe or profound mental retardation and self-injurious behaviors. During naltrexone administration, there were fewer days with frequent head-banging and self-biting. Experimental subjects were also found to sleep significantly less than controls both before and during…

Prader-Willi syndrome is a multisystem neurogenetic obesity disorder with behavioral manifestations, including hyperphagia, compulsive behavior, self-injury, and mild to moderate mental retardation. In an 8-week open-label study, we evaluated adjunctive therapy with the anticonvulsant topiramate in 8 adults with Prader-Willi syndrome. Appetite was…