Histone acetylation, catalyzed by e, has emerged as a promising therapeutic strategy in Alzheimer's disease (AD). By longitudinally characterizing spatial memory at 3, 6, and 9 mo of age, we show that acute activation and inhibition of the histone acetyltransferase PCAF remediated memory impairments in 3xTG-AD mice in an age-related bidirectional…

Adults and children (5- and 8-year-olds) performed a temporal bisection task with either auditory or visual signals and either a short (0.5-1.0s) or long (4.0-8.0s) duration range. Their working memory and attentional capacities were assessed by a series of neuropsychological tests administered in both the auditory and visual modalities. Results…

Objective: To study the effects of green tea extract administration on age-related cognition in young and old male Wistar rats. Methods: Young and old rats were orally administered 0.5% green tea extract for a period of eight weeks and were evaluated by passive avoidance, elevated maze plus paradigm and changes in acetylcholinesterase activity.…

A recall paradigm tested twenty-four 5-year-olds and twenty-four adults on short-term recognition memory for briefly presented visual information. Results indicate that processes other than verbal labeling are probably more responsible for age differences in immediate memory performance than labeling. (JH)

Five-year-olds, 9-year-olds, and adults were compared in a successive tachistoscopic recognition task in which size of the first array and the interval between the first array and the second single recognition-test stimulus were varied. (Author/SB)

Explores the nature and consequences of developmental change in speed of information processing. Summarizes evidence indicating that age differences in processing speed reflect a global mechanism that limits processing speed on most tasks. Describes evidence that suggests a role for processing speed on the development of intelligence. (Author/MKA)

Two experiments investigate the changes in the accuracy of children's cognitive maps of a large-scale environment that occur as a function of specific and repeated experience. Subjects were 20 boys and girls of three grade levels: kindergarten, second and fifth grades. (MP)

Examined the effect of monetary incentives on word list memory. Subjects were 72 children from grades 4, 6, and 8. (BD)

This experiment investigated age differences in memory performance and the extent to which rehearsal techniques contribute to these differences. Second and sixth grade children were trained in a variety of rehearsal techniques in an overt-rehearsal free recall task. (Author/SB)

In this study, third and sixth graders were tested in a recognition memory task with short lists of items from either one or two categories to investigate the influence of categorical information on retrieval processes. (Author/SB)

The relative effectiveness of semantic and structural retrieval cues was examined in men of three age groups: Group 1 (aged 20-39), Group 2 (aged 40-59), and Group 3 (aged 60-80). (Author/JMB)

Kindergarten and third grade subjects were timed while they verified sentences that paired animal names and properties varying in saliency and type of meaning. Results showed kindergarteners to be as adept as third graders in retrieving functional meaning that was highly salient and dynamic. (Author/JMB)

This study examined mental age differences in the ability of educable retarded children to predict their recognition accuracy when recall failed. Results are discussed in terms of the complexity of the metamemory judgment required. (Author/JMB)

Investigates whether age differences in memory span are affected by type of material, with the aim of making inferences about capacity. Subjects were 30 boys and girls from each of three elementary school grade levels (first, third and sixth). (Author/MP)

This study examined (1) whether subjects of different ages tend to rely on different kinds of visual information when given a choice; and (2) whether the ability to use spatial and identity information accurately in a recognition task changes developmentally. (Author/SB)