The purpose of this qualitative descriptive study was to explore how agency service providers describe their practices for building autonomy and relatedness for trafficked homeless youth in the Southeast. The theoretical foundation was self-determination theory, with a focus on the components of autonomy and relatedness. The guiding research questions of the study were seeking agency service provider descriptions of their interactions that build autonomy and relatedness while working with trafficked homeless youth survivors. The participants were human service professionals from agencies that serve trafficked homeless youth in the Southeast United States. This study utilized qualitative methodology with a descriptive study design. To answer the research questions, data was collected from 10 semi-structured interviews and a five-member focus group. The interviews and the focus group were analyzed via thematic analysis. The findings of the study supported the theoretical foundation, self-determination theory, and revealed that service providers utilize case management, trauma-informed practices, multi-agency collaboration, a supportive adult, and peer support to build autonomy and relatedness with trafficked homeless youth. [The dissertation citations contained here are published with the permission of ProQuest LLC. Further reproduction is prohibited without permission. Copies of dissertations may be obtained by Telephone (800) 1-800-521-0600. Web page: http://www.proquest.com/en-US/products/dissertations/individuals.shtml.]