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Direct linkRogers, Julie M.; Weaver, Amy L.; Havyer, Rachel D. – American Journal on Intellectual and Developmental Disabilities, 2022
Down syndrome (DS) research is advancing rapidly, yet efforts have raised ethical questions. This mixed methods study describes views of people with DS (self-advocates) and their parents regarding medical interventions for DS. Responses from 35/171 (20.5%) self-advocates and 430/867 (49.6%) parents showed the majority of self-advocates were glad…
Descriptors: Down Syndrome, Intervention, Self Concept, Parent Attitudes
Handen, Benjamin L. – American Journal on Intellectual and Developmental Disabilities, 2020
Adults with Down syndrome are at high risk for Alzheimer's disease (AD), with most individuals developing clinical dementia by their late 60s. This increased risk for AD has been attributed, at least in part, to triplication and overexpression of the gene for amyloid precursor protein (APP) on chromosome 21, leading to elevated levels of amyloid…
Descriptors: Adults, Down Syndrome, Alzheimers Disease, At Risk Persons
Smith, Elizabeth; Hedge, Craig; Jarrold, Christopher – American Journal on Intellectual and Developmental Disabilities, 2019
Executive function (EF) decline is a consistent early sign of Alzheimer's disease (AD) among adults with Down syndrome (DS), which means that baseline measures of EF for individuals with DS are vital to allow detection of meaningful decline. We developed a framework to extract measures of three core components of EF (memory updating, inhibitory,…
Descriptors: Executive Function, Down Syndrome, Identification, Clinical Diagnosis
Urv, Tiina K.; Zigman, Warren B.; Silverman, Wayne – American Journal on Intellectual and Developmental Disabilities, 2010
Changes in psychiatric symptoms related to specific stages of dementia were investigated in 224 adults 45 years of age or older with Down syndrome. Findings indicate that psychiatric symptoms are a prevalent feature of dementia in the population with Down syndrome and that clinical presentation is qualitatively similar to that seen in Alzheimer's…
Descriptors: Alzheimers Disease, Down Syndrome, Psychological Patterns, Psychiatry
