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Sanders, Erin M.; Nyarko-Odoom, Akua O.; Zhao, Kevin; Nguyen, Michael; Liao, Hong Hong Liao; Keith, Matthew; Pyon, Jane; Kozma, Alyssa; Sanyal, Mohima; McHail, Daniel G.; Dumas, Theodore C. – Learning & Memory, 2018
N-methyl-D-aspartate receptors (NMDARs) at excitatory synapses are central to activity-dependent synaptic plasticity and learning and memory. NMDARs act as ionotropic and metabotropic receptors by elevating postsynaptic calcium concentrations and by direct intracellular protein signaling. In the forebrain, these properties are controlled largely…
Descriptors: Learning, Long Term Memory, Statistical Analysis, Spatial Ability
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MacQueen, David A.; Dalrymple, Savannah R.; Drobes, David J.; Diamond, David M. – Learning & Memory, 2016
Developed as a tool to assess working memory capacity in rodents, the odor span task (OST) has significant potential to advance drug discovery in animal models of psychiatric disorders. Prior investigations indicate OST performance is impaired by systemic administration of N-methyl-D-aspartate receptor (NMDA-r) antagonists and is sensitive to…
Descriptors: Short Term Memory, Animals, Drug Use, Psychiatry
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Carmack, Stephanie A.; Howell, Kristin K.; Rasaei, Kleou; Reas, Emilie T.; Anagnostaras, Stephan G. – Learning & Memory, 2014
Methylphenidate (MPH), introduced more than 60 years ago, accounts for two-thirds of current prescriptions for attention deficit hyperactivity disorder (ADHD). Although many studies have modeled MPH's effect on executive function, almost none have directly modeled its effect on long-term memory (LTM), even though improvement in LTM is a…
Descriptors: Animals, Drug Use, Long Term Memory, Fear
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Felsenberg, Johannes; Plath, Jenny Aino; Lorang, Steven; Morgenstern, Laura; Eisenhardt, Dorothea – Learning & Memory, 2014
In classical conditioning, the temporal sequence of stimulus presentations is critical for the association between the conditioned stimulus (CS) and the unconditioned stimulus (US). In forward conditioning, the CS precedes the US and is learned as a predictor for the US. Thus it acquires properties to elicit a behavioral response, defined as…
Descriptors: Short Term Memory, Long Term Memory, Animals, Stimuli
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Levitan, David; Lyons, Lisa C.; Perelman, Alexander; Green, Charity L.; Motro, Benny; Eskin, Arnold; Susswein, Abraham J. – Learning & Memory, 2008
Training with inedible food in "Aplysia" increased expression of the transcription factor C/EBP in the buccal ganglia, which primarily have a motor function, but not in the cerebral or pleural ganglia. C/EBP mRNA increased immediately after training, as well as 1-2 h later. The increased expression of C/EBP protein lagged the increase in mRNA.…
Descriptors: Long Term Memory, Eating Habits, Stimuli, Neurological Organization
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Frey, Julietta U.; Korz, Volker; Uzakov, Shukhrat – Learning & Memory, 2005
Hippocampal long-term potentiation (LTP) can be dissociated in early-LTP lasting 4-5 h and late-LTP with a duration of more than 8 h, the latter of which requires protein synthesis and heterosynaptic activity during its induction. Previous studies in vivo have shown that early-LTP in the dentate gyrus can protein synthesis-dependently be…
Descriptors: Foreign Countries, Long Term Memory, Comparative Analysis, Brain
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Daumas, Stephanie; Halley, Helene; Frances, Bernard; Lassalle, Jean-Michel – Learning & Memory, 2005
Studies on human and animals shed light on the unique hippocampus contributions to relational memory. However, the particular role of each hippocampal subregion in memory processing is still not clear. Hippocampal computational models and theories have emphasized a unique function in memory for each hippocampal subregion, with the CA3 area acting…
Descriptors: Conditioning, Fear, Recognition (Psychology), Animals