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Peer reviewedQuinn, Declan; Wigal, Sharon; Swanson, James; Hirsch, Sharon; Ottolini, Yvonne; Dariani, Maghsoud; Roffman, Mark; Zeldis, Jerome; Cooper, Thomas – Journal of the American Academy of Child and Adolescent Psychiatry, 2004
Objective: Methylphenidate has four optical isomers due to two asymmetries (erythro-threo and dextro-levo). The initial commercial formulation eliminated the erythro isomer, but the dextro-levo asymmetry was racemic, with equal amounts of d and l-threo isomers (d,l-MPH). Previous work has suggested that the d-threo isomer methylphenidate (d-MPH)…
Descriptors: Hyperactivity, Attention Deficit Disorders, Drug Therapy, Children
Peer reviewedMullins, Celine; Bellgrove, Mark A.; Gill, Michael; Robertson, Ian H. – Journal of the American Academy of Child and Adolescent Psychiatry, 2005
Objective: To examine the relationship between time reproduction, performance variability, and sustained attention deficits in children with attention-deficit/hyperactivity disorder (ADHD) combined (ADHD-C) and inattentive (ADHD-I) subtypes, relative to matched controls. Method: Participants (age range 7.1-14.1 years) performed a time reproduction…
Descriptors: Time Management, Intervals, Hyperactivity, Attention Deficit Disorders
Peer reviewedMcGough, James J.; Biederman, Joseph; Wigal, Sharon B.; Lopez, Frank A.; McCracken, James T.; Spencer, Thomas; Zhang, Yuxin; Tulloch, Simon J. – Journal of the American Academy of Child and Adolescent Psychiatry, 2005
Objective: To evaluate the long-term tolerability and effectiveness of extended-release mixed amphetamine salts (MAS XR; Adderall XR[R]) in children with attention-deficit/hyperactivity disorder (ADHD). Method: This was a 24-month, multicenter, open-label extension of TWO placebo-controlled studies of MAS XR in children with ADHD aged 6 to 12…
Descriptors: Hyperactivity, Attention Deficit Disorders, Drug Therapy, Children
Peer reviewedKonrad, Kerstin; Gunther, Thomas; Hanisch, Charlotte; Herpertz-Dahlmann, Beate – Journal of the American Academy of Child and Adolescent Psychiatry, 2004
Objective: To examine the effects of methylphenidate on different attentional functions and behavior in children with attention-deficit-hyperactivity disorder (ADHD). Method: A total of 60 ADHD children aged between 8 and 12 years completed a randomized, double-blind, placebo-controlled, within-subject crossover trial with two doses of…
Descriptors: Behavior Rating Scales, Hyperactivity, Attention Deficit Disorders, Drug Therapy
Peer reviewedWeiss, Margaret; Wasdell, Michael; Patin, John – Journal of the American Academy of Child and Adolescent Psychiatry, 2004
Objective: To evaluate clinical measures of the benefit/risk ratio in a post hoc analysis of a clinical trial of d-threo-methylphenidate hydrochloride (d-MPH) and d,l-threo-methylphenidate hydrochloride (d,l-MPH). Method: Data from a phase III clinical trial was used to compare equimolar doses of d-MPH and d,l-MPH treatment for…
Descriptors: Psychiatry, Hyperactivity, Attention Deficit Disorders, Drug Therapy
Direct linkSchmitz, Marcelo; Denardin, Daniel; Silva, Tatiana Laufer; Pianca, Thiago; Hutz, Mara Helena; Faraone, Stephen; Rohde, Luis Augusto – Journal of the American Academy of Child and Adolescent Psychiatry, 2006
Objective: Few previous studies assessed specifically attention-deficit/hyperactivity disorder, predominantly inattentive subtype (ADHD-I) in nonreferred samples. This study investigated the association between ADHD-I and prenatal exposure to nicotine. Method: In a case-control study performed between September 2002 and April 2005, we assessed a…
Descriptors: Pregnancy, Mothers, Hyperactivity, Drinking
Peer reviewedWigal, Sharon; Swanson, James M.; Feifel, David; Sangal, R. Bart; Elia, Josephine; Casat, Charles D.; Zeldis, Jerome B.; Conners, C. Keith – Journal of the American Academy of Child and Adolescent Psychiatry, 2004
Objective: To evaluate the efficacy and safety of dexmethylphenidate hydrochloride (d-MPH, Focalin[TM]) for the treatment of attention-deficit/hyperactivity disorder (ADHD) and to test an a priori hypothesis that d-MPH would have a longer duration of action than d,l-threo-methylphenidate (d,l-MPH). Method: This was a randomized, double-blind study…
Descriptors: Hyperactivity, Attention Deficit Disorders, Drug Therapy, Children
Peer reviewedLevy, Florence; Hay, David A.; Bennett, Kellie S.; McStephen, Michael – Journal of the American Academy of Child and Adolescent Psychiatry, 2005
Objective: To examine gender differences in attention-deficit/hyperactivity disorder ("ADHD") symptom comorbidity with "oppositional defiant disorder", "conduct disorder", "separation anxiety disorder", "generalized anxiety disorder", speech therapy, and remedial reading in children. Method: From…
Descriptors: Remedial Reading, Speech Therapy, Siblings, Separation Anxiety
Kennard, Betsy; Silva, Susan; Vitiello, Benedetto; Curry, John; Kratochvil, Christopher; Simons, Anne; Hughes, Jennifer; Feeny, Norah; Weller, Elizabeth; Sweeney, Michael; Reinecke, Mark; Pathak, Sanjeev; Ginsburg, Golda; Emslie, Graham; March, John – Journal of the American Academy of Child and Adolescent Psychiatry, 2006
Objective: To ascertain remission rates in depressed youth participating in the Treatment for Adolescents With Depression Study (TADS), a multisite clinical trial that randomized 439 adolescents with major depressive disorder (MDD) to a 12-week treatment of fluoxetine (FLX), cognitive-behavioral therapy (CBT), their combination (COMB), or clinical…
Descriptors: Adolescents, Depression (Psychology), Outcomes of Treatment, Symptoms (Individual Disorders)
Peer reviewedPearson, Deborah A.; Santos, Cynthia W.; Casat, Charles D.; Lane, David M.; Jerger, Susan W.; Roache, John D.; Loveland, Katherine A.; Lachar, David; Faria, Laura P.; Payne, Christa D.; Cleveland, Lynne A. – Journal of the American Academy of Child and Adolescent Psychiatry, 2004
Objective: Cognitive effects of stimulant medication were investigated in children with mental retardation (MR) and attention-deficit/hyperactivity disorder (ADHD). Method: Performance on tasks tapping sustained attention, visual and auditory selective attention, inhibition, and immediate memory was assessed for 24 children (mean age 10.9 years)…
Descriptors: Stimulants, Mental Retardation, Inhibition, Hyperactivity
Peer reviewedWeiss, Margaret; Tannock, Rosemary; Kratochvil, Christopher; Dunn, David; Velez-Borras, Jesus; Thomason, Christine; Tamura, Roy; Kelsey, Douglas; Stevens, Linda; Allen, Albert J. – Journal of the American Academy of Child and Adolescent Psychiatry, 2005
Objective: Five studies have demonstrated the effectiveness of atomoxetine compared with placebo in reducing symptoms of attention-deficit/hyperactivity disorder (ADHD) based on parent reports. The primary objective of this clinical trial was to assess the efficacy of once-daily atomoxetine compared with placebo using teacher reports. Method: One…
Descriptors: Measures (Individuals), Symptoms (Individual Disorders), Student Behavior, Hyperactivity
