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Direct linkPaterson, Sarah J.; Parish-Morris, Julia; Hirsh-Pasek, Kathryn; Golinkoff, Roberta Michnick – Journal of Cognition and Development, 2016
Various theorists have argued for the importance of a developmental approach to studying typical development (Karmiloff-Smith, 1998; Lerner, 1996; Lerner & Hood, 1986; Masten & Cicchetti, 2010; Overton, 2014; Overton & Lerner, 2012, 2014), and there are reasons to believe that this issue is even more critical to the study of…
Descriptors: Developmental Disabilities, Brain, Child Development, Developmental Stages
Sage, Cindy; Burgio, Ernesto – Child Development, 2018
Mobile phones and other wireless devices that produce electromagnetic fields (EMF) and pulsed radiofrequency radiation (RFR) are widely documented to cause potentially harmful health impacts that can be detrimental to young people. New epigenetic studies are profiled in this review to account for some neurodevelopmental and neurobehavioral changes…
Descriptors: Child Development, Genetics, Telecommunications, Handheld Devices
Tillmann, J.; Ashwood, K.; Absoud, M.; Bölte, S.; Bonnet-Brilhault, F.; Buitelaar, J. K.; Calderoni, S.; Calvo, R.; Canal-Bedia, R.; Canitano, R.; De Bildt, A.; Gomot, M.; Hoekstra, P. J.; Kaale, A.; McConachie, H.; Murphy, D. G.; Narzisi, A.; Oosterling, I.; Pejovic-Milovancevic, M.; Persico, A. M.; Puig, O.; Roeyers, H.; Rommelse, N.; Sacco, R.; Scandurra, V.; Stanfield, A. C.; Zander, E.; Charman, T. – Journal of Autism and Developmental Disorders, 2018
Research on sex-related differences in Autism Spectrum Disorder (ASD) has been impeded by small samples. We pooled 28 datasets from 18 sites across nine European countries to examine sex differences in the ASD phenotype on the ADI-R (376 females, 1763 males) and ADOS (233 females, 1187 males). On the ADI-R, early childhood restricted and…
Descriptors: Gender Differences, Age Differences, Diagnostic Tests, Observation
Van Den Heuvel, Ellen; Manders, Eric; Swillen, Ann; Zink, Inge – Journal of Intellectual & Developmental Disability, 2017
Background: Children with 22q11.2 deletion syndrome (22q11.2DS) are reported to have socio-communicative impairments. Although many of these children are diagnosed with intellectual disability (ID) and/or autism spectrum disorder (ASD), these populations are seldom used as control groups. Hence, information regarding syndrome-specific…
Descriptors: Genetic Disorders, Communication Problems, Interpersonal Competence, Interpersonal Communication
Pescosolido, Matthew F.; Gamsiz, Ece D.; Nagpal, Shailender; Morrow, Eric M. – Journal of the American Academy of Child & Adolescent Psychiatry, 2013
Objective: The purpose of the present study was to discover the extent to which distinct "DSM" disorders share large, highly recurrent copy number variants (CNVs) as susceptibility factors. We also sought to identify gene mechanisms common to groups of diagnoses and/or specific to a given diagnosis based on associations with CNVs. Method:…
Descriptors: Diseases, Genetics, Autism, Schizophrenia
Morrow, Eric M. – Journal of the American Academy of Child & Adolescent Psychiatry, 2010
Objective: To highlight recent discoveries in the area of genomic copy number variation in neuropsychiatric disorders including intellectual disability, autism, and schizophrenia. To emphasize new principles emerging from this area, involving the genetic architecture of disease, pathophysiology, and diagnosis. Method: Review of studies published…
Descriptors: Mental Retardation, Schizophrenia, Autism, Clinical Diagnosis
Frolli, A.; Piscopo, S.; Conson, M. – Journal of Intellectual Disability Research, 2015
Background: Individuals with fragile-X syndrome exhibit developmental delay, hyperexcitation and social anxiety; they also show lack of attention and hyperactivity. Few studies have investigated whether levels of functioning change with increasing age. Here, we explored developmental changes across adolescence in the cognitive and behavioural…
Descriptors: Adolescents, Genetic Disorders, Developmental Delays, Anxiety
Hammock, Elizabeth; Veenstra-VanderWeele, Jeremy; Yan, Zhongyu; Kerr, Travis M.; Morris, Marianna; Anderson, George M.; Carter, C. Sue; Cook, Edwin H.; Jacob, Suma – Journal of the American Academy of Child & Adolescent Psychiatry, 2012
Objective: Autism spectrum disorder (ASD) is a heritable but highly heterogeneous neuropsychiatric syndrome, which poses challenges for research relying solely on behavioral symptoms or diagnosis. Examining biomarkers may give us ways to identify individuals who demonstrate specific developmental trajectories and etiological factors related to…
Descriptors: Animals, Autism, Symptoms (Individual Disorders), Brain
Thompson, Travis – Journal of Applied Research in Intellectual Disabilities, 2013
For three decades after Leo Kanner's first clinical description, research progress in understanding and treating autism was minimal but since the late 1960s the growth of autism discoveries has been exponential, with a remarkable number of new findings published over the past two decades, in particular. These advances were made possible first by…
Descriptors: Autism, Research, Young Children, Brain Hemisphere Functions
Peters, Sarika U.; Horowitz, Lucia; Barbieri-Welge, Rene; Taylor, Julie Lounds; Hundley, Rachel J. – Journal of Child Psychology and Psychiatry, 2012
Background: Angelman syndrome (AS) is a neurogenetic disorder characterized by severe intellectual disability, lack of speech, and low threshold for laughter; it is considered a "syndromic" form of autism spectrum disorder (ASD). Previous studies have indicated overlap of ASD and AS, primarily in individuals with larger (approximately 6 Mb) Class…
Descriptors: Mental Retardation, Autism, Adjustment (to Environment), Severity (of Disability)
Grafodatskaya, Daria; Chung, Brian; Szatmari, Peter; Weksberg, Rosanna – Journal of the American Academy of Child & Adolescent Psychiatry, 2010
Objective: Current research suggests that the causes of autism spectrum disorders (ASD) are multifactorial and include both genetic and environmental factors. Several lines of evidence suggest that epigenetics also plays an important role in ASD etiology and that it might, in fact, integrate genetic and environmental influences to dysregulate…
Descriptors: Evidence, Autism, Genetics, Etiology
Hoffman, Ellen J.; State, Matthew W. – Journal of the American Academy of Child & Adolescent Psychiatry, 2010
Objective: This review considers the impact of chromosomal studies on the understanding of childhood neuropsychiatric syndromes, highlighting key discoveries, advances in technology, and new challenges faced by clinicians trying to interpret recent findings. Method: We review the literature on the genetics of child psychiatric disorders, including…
Descriptors: Attention Deficit Hyperactivity Disorder, Investigations, Schizophrenia, Emotional Disturbances
van Balkom, I. D. C.; Shaw, A.; Vuijk, P. J.; Franssens, M.; Hoek, H. W.; Hennekam, R. C. M. – Journal of Intellectual Disability Research, 2011
Background: Marshall-Smith syndrome (MSS) is an infrequently described entity characterised by failure to thrive, developmental delay, abnormal bone maturation and a characteristic face. In studying the physical features of a group of patients, we noticed unusual behavioural traits. This urged us to study cognition, behavioural phenotype and…
Descriptors: Mental Retardation, Autism, Developmental Delays, Communication Skills
Macarov, M.; Zeigler, M.; Newman, J. P.; Strich, D.; Sury, V.; Tennenbaum, A.; Meiner, V. – Journal of Intellectual Disability Research, 2007
Background: Patients with Xp22.3 interstitial and terminal deletions have been shown to be affected by intellectual disability (ID) or autism. Previously, "VCX-A" (variably charged protein X-A), located at Xp22.3, was introduced as a gene for ID and its presence was suggested to be sufficient to maintain normal mental development. Recent reports…
Descriptors: Patients, Cognitive Development, Autism, Genetics
Wassink, Thomas H.; Brzustowicz, Linda M.; Bartlett, Christopher W.; Szatmari, Peter – Mental Retardation and Developmental Disabilities Research Reviews, 2004
Autism is a heritable disorder characterized by phenotypic and genetic complexity. This review begins by surveying current linkage, gene association, and cytogenetic studies performed with the goal of identifying autism disease susceptibility variants. Though numerous linkages and associations have been identified, they tend to diminish upon…
Descriptors: Autism, Diseases, Cognitive Development, Genetics
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