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| Research in Developmental… | 7 |
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Peer reviewedGroden, Gerald; And Others – Research in Developmental Disabilities, 1987
The study of use of the drug fenfluramine with four autistic children (7-20 years old) indicated no significant side effects, a reduction in some deviant behaviors, and an improvement in activity level/attention span. (Author/DB)
Descriptors: Adolescents, Attention Span, Autism, Behavior Change
Peer reviewedSzymanski, Ludwik; And Others – Research in Developmental Disabilities, 1987
The oral opiate, naltrexone, was used in a double-blind placebo-controlled study with two young profoundly mentally adults who exhibited intractable self-injurious behavior. No measurable effects on the self-injurious behavior were observed. (Author/DB)
Descriptors: Behavior Change, Behavior Problems, Drug Therapy, Outcomes of Treatment
Peer reviewedMillichamp, C. Jane; Singh, Nirbhay N. – Research in Developmental Disabilities, 1987
A double-blind placebo-controlled study was conducted to assess the effects of intermittent drug therapy on stereotyped and collateral behaviors of six profoundly mentally retarded, institutionalized, adult males. Despite a marked reduction in medication, there was no general change of clinical significance in any of the behaviors. (Author/DB)
Descriptors: Adults, Behavior Change, Drug Therapy, Institutionalized Persons
Peer reviewedCrews, W. David, Jr.; And Others – Research in Developmental Disabilities, 1993
This case study of a woman with profound mental retardation and a history of severe self-injurious behavior (SIB) found that the dramatic decrease in SIB following Naltrexone administration was maintained through placebo and no drug phases and at six-month follow-up. Findings are discussed in terms of endogenous opioid system theories of SIB. (DB)
Descriptors: Adults, Behavior Change, Biochemistry, Case Studies
Peer reviewedGarcia, David; Smith, Richard G. – Research in Developmental Disabilities, 1999
A study administered Naltrexone (NLTX) to two adult females with profound mental retardation who engaged in self-injurious behavior (SIB). For one participant, NLTX produced slight reductions in SIB across baseline conditions. The second participant's results showed NLTX reduced head-slapping during demand sessions but had no apparent effect on…
Descriptors: Adults, Behavior Change, Drug Therapy, Females
Peer reviewedSingh, Nirbhay N.; And Others – Research in Developmental Disabilities, 1993
This study of three individuals (ages 12-14) with profound mental retardation found that visual screening was more effective than thioridazine in reducing stereotypy and increasing social behavior. Thioridazine produced modest stereotypy reductions and minor social behavior increases, with a higher dose slightly more effective than a lower dose…
Descriptors: Adolescents, Behavior Change, Behavior Problems, Drug Therapy
Peer reviewedCrews, W. David, Jr.; Rhodes, Robert D.; Bonaventura, Sharon H.; Rowe, Frederick B.; Goering, Aaron M. – Research in Developmental Disabilities, 1999
Longitudinal follow-ups of the cessation of long-term Naltrexone administration were conducted with a women with profound mental retardation who had previously displayed dramatic decreases in self-injurious behavior (SIB). After two and four years post-Naltrexone therapy, the subject exhibited near-zero rates of SIB despite changes in staff and in…
Descriptors: Adults, Behavior Change, Drug Therapy, Followup Studies
