Individuals who engage in problem behavior receive treatment services in various settings, such as their homes, schools, and clinics. These individuals are also likely to experience treatment provision from various practitioners, such as therapists, teachers, and caregivers. Changes in the treatment setting or intervention agent (i.e., context) can cause renewal of problem behavior. Renewal is the form of relapse that occurs when a previously eliminated behavior returns due to a change in context. Practitioners should know six things about renewal to improve clinical practice: (1) generality of renewal; (2) potential for renewal even when alternative reinforcement is available; (3) similarity between renewal testing procedures and situations that practitioners commonly encounter; (4) close relationship between renewal and the generalization of behavior change; (5) distinction between renewal and another form of relapse (i.e., resurgence); and (6) potential mitigation strategies. Practitioners should prepare for renewal during context changes when working with their clients, especially during changes to the treatment setting or intervention agent.