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Direct linkWen-Xiong Chen; Yi-Ru Chen; Min-Zhi Peng; Xian Liu; Yan-Na Cai; Zhi-Fang Huang; Si-Yuan Yang; Jing-Yu Huang; Ruo-Han Wang; Peng Yi; Li Liu – Journal of Autism and Developmental Disorders, 2024
To retrospectively explore the characteristics of plasma amino acids (PAAs) in children with autism spectrum disorder and their clinical association via case-control study. A total of 110 autistic and 55 healthy children were recruited from 2014 to 2018. The clinical phenotypes included severity of autism, cognition, adaptability, and regression.…
Descriptors: Autism Spectrum Disorders, Severity (of Disability), Foreign Countries, Comparative Analysis
Mowrer, Emily R.; Potratz, Jeffrey P. – Journal of Chemical Education, 2020
Categorizing the various levels of protein and nucleic acid structures is a relatively straightforward concept students understand quickly when shown representative structural images. However, keeping in mind the idea of primary, secondary, and tertiary structure proves more difficult when students are in the laboratory setting simply looking at a…
Descriptors: Genetics, Teaching Methods, Science Education, Laboratory Experiments
Asmus, Stephen E.; Szalanczy, Alexandria M.; Murray, Shannon K.; Overstreet, Spencer A.; Vokoun, Amanda R. – Journal of Biological Education, 2020
Programmed cell death, or apoptosis, is a cellular pathway by which individual cells self-destruct for the benefit of the organism. In this practical paper, we describe laboratory exercises with an inquiry-based learning (IBL) approach in which undergraduate students compared apoptosis among different types of cultured cells. Ultraviolet (UV)…
Descriptors: Cytology, Science Instruction, Animals, Laboratory Experiments
Marchal, Paul; Villar, Maria Eugenia; Geng, Haiyang; Arrufat, Patrick; Combe, Maud; Viola, Haydée; Massou, Isabelle; Giurfa, Martin – Learning & Memory, 2019
Honeybees are a standard model for the study of appetitive learning and memory. Yet, fewer attempts have been performed to characterize aversive learning and memory in this insect and uncover its molecular underpinnings. Here, we took advantage of the positive phototactic behavior of bees kept away from the hive in a dark environment and…
Descriptors: Inhibition, Learning Processes, Memory, Molecular Structure
Deutch, Charles E. – Biochemistry and Molecular Biology Education, 2018
Many fruits and vegetables undergo browning when they are cut and the tissue is exposed to the air. This is due to the activity of the enzyme polyphenol oxidase (PPO, EC 1.14.18.1) with endogenous substrates. In this laboratory experiment, students prepare slices of different varieties of apples and assess the rate of browning. They make a simple…
Descriptors: Biochemistry, Genetics, Teaching Methods, Comparative Analysis
Wasim, Muhammad; Khan, Haq Nawaz; Ayesha, Hina; Awan, Fazli Rabbi – International Journal of Developmental Disabilities, 2020
Objectives: Inborn errors of metabolism (IEMs) are rare genetic disorders. Generally, IEMs are untreatable; however, some IEMs causing intellectual disability are potentially treatable if diagnosed earlier. In this study, levels of some clinically important biochemical parameters in intellectually disabled children suspected for IEMs were tested…
Descriptors: Biochemistry, Screening Tests, Foreign Countries, Metabolism
Siu, Michelle T.; Goodman, Sarah J.; Yellan, Isaac; Butcher, Darci T.; Jangjoo, Maryam; Grafodatskaya, Daria; Rajendram, Rageen; Lou, Youliang; Zhang, Rujun; Zhao, Chunhua; Nicolson, Rob; Georgiades, Stelios; Szatmari, Peter; Scherer, Stephen W.; Roberts, Wendy; Anagnostou, Evdokia; Weksberg, Rosanna – Journal of Autism and Developmental Disorders, 2021
Many neurodevelopmental disorders (NDDs) share common learning and behavioural impairments, as well as features such as dysregulation of the oxytocin hormone. Here, we examined DNA methylation (DNAm) in the 1st intron of the oxytocin receptor gene, "OXTR," in patients with autism spectrum (ASD), attention deficit and hyperactivity (ADHD)…
Descriptors: Genetics, Autism, Pervasive Developmental Disorders, Biochemistry
Carvalho Pereira, Andreia; Violante, Inês R.; Mouga, Susana; Oliveira, Guiomar; Castelo-Branco, Miguel – Journal of Autism and Developmental Disorders, 2018
The nature of neurochemical changes in autism spectrum disorder (ASD) remains controversial. We compared medial prefrontal cortex (mPFC) neurochemistry of twenty high-functioning children and adolescents with ASD without associated comorbidities and fourteen controls. We observed reduced total N-acetylaspartate (tNAA) and total creatine, increased…
Descriptors: Autism, Pervasive Developmental Disorders, Adolescents, Brain Hemisphere Functions
Demirci, Nevzat – Educational Research and Reviews, 2015
This study was conducted in order to know the impact of coenzyme Q[subscript 10] (CoQ[subscript 10]) supplement on the muscle damage and total oxidant (TOS) enzyme levels of young skiing athletes during exercise. 15 male athletes were used for two weeks in the study. The athletes were divided into three groups: the control group and two subject…
Descriptors: Injuries, Genetics, Recreational Activities, Males
Southard, Katelyn M.; Espindola, Melissa R.; Zaepfel, Samantha D.; Bolger, Molly S. – International Journal of Science Education, 2017
When conducting scientific research, experts in molecular and cellular biology (MCB) use specific reasoning strategies to construct mechanistic explanations for the underlying causal features of molecular phenomena. We explored how undergraduate students applied this scientific practice in MCB. Drawing from studies of explanation building among…
Descriptors: Molecular Biology, Biology, Science Instruction, Qualitative Research
Genetic Moderation of Cortisol Secretion in Holocaust Survivors: A Pilot Study on the Role of ADRA2B
Fridman, Ayala; van IJzendoorn, Marinus H.; Sagi-Schwartz, Abraham; Bakermans-Kranenburg, Marian J. – International Journal of Behavioral Development, 2012
In the current study we tested whether "ADRA2B" moderates stress regulation of Holocaust survivors as indexed by their diurnal cortisol secretion and cortisol reactivity to a stressor. Salivary cortisol levels of 54 female Holocaust survivors and participants in the comparison group were assessed during a routine day and in response to a…
Descriptors: Biochemistry, Genetics, Stress Variables, Death
Eirin-Lopez, Jose M. – Biochemistry and Molecular Biology Education, 2013
The study of chromatin constitutes one of the most active research fields in life sciences, being subject to constant revisions that continuously redefine the state of the art in its knowledge. As every other rapidly changing field, chromatin biology requires clear and straightforward educational strategies able to efficiently translate such a…
Descriptors: Undergraduate Students, Information Science, Evolution, Physics
Bowling, Bethany; Zimmer, Erin; Pyatt, Robert E. – American Biology Teacher, 2014
Although the development of next-generation (NextGen) sequencing technologies has revolutionized genomic research and medicine, the incorporation of these topics into the classroom is challenging, given an implied high degree of technical complexity. We developed an easy-to-implement, interactive classroom activity investigating the similarities…
Descriptors: Molecular Biology, Class Activities, Teaching Methods, Educational Practices
Colzato, Lorenza S.; Waszak, Florian; Nieuwenhuis, Sander; Posthuma, Danielle; Hommel, Bernhard – Neuropsychologia, 2010
Genetic variability related to the catechol-O-methyltransferase (COMT) gene Val[superscript 128]Met polymorphism) has received increasing attention as a possible modulator of cognitive control functions. Recent evidence suggests that the Val[superscript 128]Met genotype may differentially affect cognitive stability and flexibility, in such a way…
Descriptors: Cognitive Processes, Validity, Genetics, Biochemistry
Zhou, Chun – ProQuest LLC, 2009
RNA hypermodifications near the anticodon of tRNA are fundamental for the efficiency and fidelity of protein synthesis. Dimethylallyltransferase (DMATase) catalyzes transfer of a dimethylallyl moiety from dimethylallyl pyrophosphate to N6 of A37 in certain tRNAs. We first determined the crystal structures of "Pseudomonas aeruginosa" DMATase.…
Descriptors: Maintenance, Genetics, Microbiology, Biochemistry
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