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DNA Methylation of the Oxytocin Receptor across Neurodevelopmental Disorders
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Siu, Michelle T.; Goodman, Sarah J.; Yellan, Isaac; Butcher, Darci T.; Jangjoo, Maryam; Grafodatskaya, Daria; Rajendram, Rageen; Lou, Youliang; Zhang, Rujun; Zhao, Chunhua; Nicolson, Rob; Georgiades, Stelios; Szatmari, Peter; Scherer, Stephen W.; Roberts, Wendy; Anagnostou, Evdokia; Weksberg, Rosanna – Journal of Autism and Developmental Disorders, 2021
Many neurodevelopmental disorders (NDDs) share common learning and behavioural impairments, as well as features such as dysregulation of the oxytocin hormone. Here, we examined DNA methylation (DNAm) in the 1st intron of the oxytocin receptor gene, "OXTR," in patients with autism spectrum (ASD), attention deficit and hyperactivity (ADHD)…
Descriptors: Genetics, Autism, Pervasive Developmental Disorders, Biochemistry
Genetics of Learning Disabilites
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Rossi, Albert O. – Journal of Learning Disabilities, 1972
A constitutional genetic neurochemical dysfunction is posited as the basis of a large number of learning disabilities. (Author/GW)
Descriptors: Biochemistry, Educational Needs, Emotional Disturbances, Etiology
The Biochemical Basis of Minimal Brain Dysfunction
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Shaywitz, Sally E.; And Others – Journal of Pediatrics, 1978
Available from: C. V. Mosby Company 11830 Westline Industrial Drive St. Louis, Missouri 63141 The research review examines evidence suggesting a biochemical basis for minimal brain dysfunction (MBD), which includes both a relationship between MBD and metabolic abnormalities and a significant genetic influence on the disorder in children. (IM)
Descriptors: Biochemistry, Children, Etiology, Exceptional Child Research
Psychopathology of Mental Development (Proceedings of the Fifty-Sixth Annual Meeting of the American Psychopathological Association, Held in New York City, February, 1966).
Zubin, Joseph, Ed.; Jervis, George A., Ed. – 1967
The proceedings include 33 papers and two addresses on the psychopathology of mental development. The following six subject areas are considered: genetics and neurophysiology, socio-cultural and paranatal factors; epidemiology; behavior characteristics and learning; observational techniques and measurement of intelligence; and diagnosis and…
Descriptors: Behavior Patterns, Biochemistry, Clinical Diagnosis, Congenital Impairments