Despite much research, the role of the medial temporal lobes (MTL) in category learning is unclear. Two unstructured categorization experiments explored conditions that might recruit MTL category learning and memory systems--namely, whether the stimulus display includes one or two stimuli, and whether category membership depends on configural…

The use of mixed reality in science education has been increasing and as such it has become more important to understand how information is learned in these virtual environments. Spatial ability is important in many learning contexts, but especially in neuroanatomy education where learning the locations and spatial relationships between brain…

Learning and memory involves a large neural network of many brain regions, including the notable hippocampus along with the retrosplenial cortex (RSC) and lateral septum (LS). Previous studies have established that the dorsal hippocampus (dHPC) plays a critical role during the acquisition and retrieval/expression of episodic memories. However, the…

An essential feature of episodic memory is the ability to recall the multiple elements relating to one event from the multitude of elements relating to other, potentially similar events. Hippocampal pattern separation is thought to play a fundamental role in this process, by orthogonalizing the representations of overlapping events during…

Human communication relies on the ability to assess what others intend to communicate beyond what they directly say. Under classic theories of communication, a critical component of this process is the evaluation of what another person knows (epistemic reasoning) and how that knowledge will affect the value of what they communicate. For example, a…

Working memory (WM), the capacity for short-term storage of small quantities of information for immediate use, is thought to depend on activity within the prefrontal cortex. Recent evidence indicates that the prefrontal neuronal activity supporting WM is driven by thalamocortical connections arising in mediodorsal thalamus (mdThal). However, the…

We present evidence that experience and cholinergic modulation in an early sensory network interact to improve certainty about olfactory stimuli. The data we present are in agreement with existing theoretical ideas about the functional role of acetylcholine but highlight the importance of early sensory networks in addition to cortical networks. We…

It is well known that the semantic features of gender associated with peoples' names are represented in the conceptual semantic system. However, there is scant evidence that such knowledge plays a role in name comprehension, and if so, in which processing stage this occurs. The aim of this study was to provide evidence concerning the time course…

Metacognitive functions are important for both teachers and students to facilitate teaching and learning. The prefrontal cortex (PFC) plays a proven role in metacognition. As a pilot study, we evaluated the PFC activity of teachers and students using near-infrared spectroscopy devices to explore the neural mechanism of PFC underlying metacognitive…

The interaction between working memory and language processing is widely discussed in cognitive research. However, those studies often explore the relationship between language comprehension and working memory (WM). The role of WM is rarely considered in language production, despite some evidence suggesting a relationship between the two cognitive…

Nonprotein coding dendritic BC1 RNA regulates translation of mRNAs in neurons. We examined two lines of BC1 knockout mice and report that loss of BC1 RNA exaggerates group I mGluR-stimulated LTD of the Schaffer collateral synapse, with one of the lines showing a much more enhanced DHPG-induced LTD than the other. When the animals were given the…

Counterfactuals describe imagined alternatives to reality that people know to be false. Successful counterfactual comprehension therefore requires people to keep in mind both an imagined hypothetical world and the presupposed real world. "Counterfactual transparency," that is, the degree to which a context makes it easy to determine…

There are mixed results regarding the differentiation of neurofunctional correlates of spatial abilities. Previous studies employed complex environments or alternate memory tasks which could potentially add to inconsistencies across studies of navigation. To help elucidate the existing mixed findings, we conducted a study in a simplistic…

We investigated the in vivo role of protein degradation during intermediate (ITM) and long-term memory (LTM) in "Aplysia" using an operant learning paradigm. The proteasome inhibitor MG-132 inhibited the induction and molecular consolidation of LTM with no effect on ITM. Remarkably, maintenance of steady-state protein levels through…

The declarative/procedural (DP) model posits that the learning, storage, and use of language critically depend on two learning and memory systems in the brain: declarative memory and procedural memory. Thus, on the basis of independent research on the memory systems, the model can generate specific and often novel predictions for language. Till…