In this research, it was aimed to determine the effect of Simulation-Supported Prediction Observation Explanation (SSPOE) activities related to solid and liquid pressure on the conceptions of learning physics of 10th grade students. In the research, a quasi-experimental design with pretest-posttest control group, which is one of the quantitative research methods, was used. The sample of the research consisted of 50 students studying in the 10th grade in a technical and vocational high school in Afyonkarahisar province. The students in the Experimental 1 (E1) group carried out the SSPOE activities using a computer, and the students in the Experimental 2 (E2) group performed the SSPOE activities using a smart board in the classroom. The students in the Control group continued the current teaching process without using the SSPOE activities. Lessons were conducted by the same teacher and SSPOE activities lasted for 5 weeks. The data were collected through the Conceptions Of Learning Physics (COLP) scale before and after the application. In the analysis of the data, analysis of covariance (ANCOVA test) was performed. At the end of the analyses it can be said that the SSPOE activities are effective on the high level COLP. Learning environments where students can be active individually are more effective in improving students' conceptions of learning physics in a positive way.