Purpose: The present study aimed to integrate artificial intelligence technology (ChatGPT) with an in-depth literature review to explore knowledge dimensions of professional teaching and information and communication technology (ICT) integration models in TVET, and utilize the Delphi technique and ChatGPT to examine, enhance, and validate a newly proposed model for professional teaching and ICT integration in TVET. Methods: Three rounds of the Delphi technique were applied to develop and validate this new model. Artificial intelligence tool (ChatGPT) with an in-depth literature review were used to explore knowledge dimensions for TVET education. In Round 1, ChatGPT was used to transform the technological pedagogical content knowledge (CK) model for TVET instruction. A new suggested model was developed called the contextual technology andrology/pedagogy entrepreneurship work CK (CTA/PEWCK) model. Ten experts from the TVET sector participated in Round 2, and 39 participated in Round 3 to validate the new suggested model. Findings: The findings revealed that the fifteen knowledge dimensions extracted from this new suggested model presented essential knowledge for TVET education. Conclusion: Applying the CTA/PEWCK model offers professional development opportunities for TVET teachers that focus on hands-on experiences to develop competencies for sustainable development (ESD), enabling an integrated approach to knowledge dimensions, procedures, and attitude.