A major challenge when designing new experiments for the general chemistry laboratory is introducing students to the necessary techniques while keeping the experiment engaging and accessible. This work presents a new multiweek activity designed to introduce students to advanced instrumentation in the form of high-performance liquid chromatography…

A simple demonstration adaptable to classroom conditions is presented, which involves the preparation of raffle tickets using filter paper and the solution of selected fluorophores. With an appropriate dilution, the text written on the tickets is not visible to the naked eye; however, it becomes readable once put under a UV lamp. Besides being a…

The area near the electrode surface is called the diffusion layer, and to understand electrochemistry, it is crucial that students have a knowledge of the phenomena occurring at the diffusion layer. Here, we present a demonstration and activity to visualize and analyze the expansion of a micrometer-sized diffusion layer. The electrode process…

Electrochromism encompasses reversible changes of material's optical properties (color, opacity) under the influence of an external electric current or applied voltage. The effect has been known for decades, but its importance continues to grow due to the rapid development of smart systems and the accompanying demand to build devices that consume…

So-called "Color Wonder" markers contain colorless dyes that only display color when used to mark on special "Color Wonder" paper. These markers make use of leuco dyes that only develop color in the presence of acid. These markers provide science educators with a novel chemical system that can be implemented in inquiry-based…

Raman scattering is a powerful tool for revealing the vibrations of molecules, but as a nonlinear optical phenomenon, its signals can change via mechanisms like resonance enhancement that have no direct analogue in infrared spectroscopy. In this work, complementary measurements conducted on 4-nitrophenol and its conjugate base allow students to…

Biosphere contamination is a current environmental and social issue that must be included in the school programme. It is essential that students recognise their responsibility, and be knowledgeable about the generation and reduction of environmental pollution. Dyes are usually used in school activities and discharged into household effluents,…

A two to three period analytical chemistry experiment has been developed which allows second year students to explore chemical color tests used to detect adulterated pharmaceuticals. Students prepare several paper analytical devices (PADs) to generate positive and negative controls antibiotics, along with cutting agents such as starch and chalk.…

Given the growing prevalence of computational methods in chemistry, it is essential that undergraduate curricula introduce students to these approaches. One such area is the application of machine learning (ML) techniques to chemistry. Here we describe a new activity that applies ML regression analysis to the common physical chemistry laboratory…

The chemistry laboratory is an impactful platform for introducing inquiry and developing science practice skills. We designed a short lab course to introduce incremental levels of inquiry, also to interconnect and integrate different domains of chemistry. Indigo dye was the central theme of this short course wherein students synthesized indigo,…

The identification of coloring substances is a relevant task in the field of conservation and restoration, but it can be challenging as in real samples the target analytes are inserted in a very complex matrix made of binders and additives. Understanding this concept is fundamental for upper-division undergraduate students interested in…

We have developed a multivariate and multidisciplinary lab experiment on the synthesis of alginate hydrogel beads of various sizes and dye encapsulation for upper-division undergraduate and graduate students. This experiment introduces students to several common concepts in polymer chemistry, materials science, and drug delivery. The experiment…

We describe a paper-based microfluidic device for iron(III) assay in an applied instrumental analysis laboratory. Simple and convenient devices were fabricated by the students using patterning of filter paper to investigate three different procedures: drawing a boundary with eyeliner or wax pen; drawing a boundary with waterproof permanent marker…

Laboratory experiments provide students a tangible means of understanding dry, abstract concepts. A simple and engaging introductory wet chemistry laboratory has been developed relating quantum mechanics to color, which has been implemented for a class of about 600 students per academic year for over three years at Brown University. Color is an…

The increasing integration of software and automation in modern chemical laboratories prompts special emphasis on two important skills in the chemistry classroom. First, students need to learn the technical skills involved in modern scientific computing and automation. Second, applying these techniques in practice requires effective collaboration…