The study aimed at investigating the role of proactive personality in the relationship between the experience of parentification, psychological resilience and psychological well-being. In the study, the survey method based on quantitative data was utilized. The participants were composed of 416 university students (266 females, 150 males). The data were gathered via the Psychological Resilience Scale (PRS), the Proactive Personality Scale (PPS), the Psychological Well-Being Scale (PWBS), the Parentified Child Scale-Adult Version (PCS-A), and a personal information form. The data were analyzed via Pearson product-moment correlation coefficient and mediation analysis. The findings revealed that the experience of parentification had a negative direct effect on psychological well-being and psychological resilience, while it had an positive indirect effect on psychological well-being and psychological resilience through proactivity. In other words, as university students' level of proactivity increased, the negative effect of parentification on psychological well-being and psychological resilience decreased.