Purpose: Using data from a randomized clinical trial evaluating cognitive behavioral therapy (CBT) for children with autism and co-occurring anxiety, this study examined the relationship between autism features and anxiety symptoms throughout CBT. Methods: Two multilevel mediation analyses were run which examined the mediating role of changes in…

This paper reports on two children diagnosed as having co-occurring autistic disorder, schizophrenia-like psychosis, and Tourette syndrome, and two autistic adults who had tics and episodes of schizophrenia-like psychosis. (JDD)

Prevalence of autism in tuberous sclerosis was estimated by interviewing parents of 21 children (ages 3-11). The estimated prevalence of autism was found to be one in four children in general, and one in two of those with mental retardation. Tuberous sclerosis could be a significant cause of autism and pervasive developmental disorders,…

Repeated impedance measures were given over five weeks to 11 autistic, 20 learning-disabled, and 20 normal children. A repeated measures analysis of variance led to the conclusion that fluctuating, negative middle ear pressure greater than normal characterizes both autistic and learning-disabled children with the more abnormal pressures typical in…

Sixty-six patients under age 25 with autism and epileptic seizures were treated and followed for 2 years. The cases are analyzed in terms of type of epilepsy, drugs used, and other treatments given. Practical guidelines are offered for the management of epilepsy in autism. (Author/JDD)

This study compared the family histories of 13 children with autism or pervasive developmental disorder (PDD) with depression and 10 similar children without depression. Ten of the depressed children had a positive family history of depression compared to three of the nondepressed group. Findings support the validity of depression as a distinct…

A study investigated the incidence of autism in 20 patients with tuberous sclerosis complex (TSC). The prevalence of autistic disorder was conservatively estimated at 20%. Data suggest a possible association between both hypsarrythmia and TSC-related cardiac abnormalities with autism in this subgroup of individuals with TSC. (Author/CR)

A study involving 47 families of individuals (ages 4-34) with autism and severe mental retardation found the familial loading for autism and for the broader phenotype was closely comparable to that in a study of children with higher IQ autism, and different from that for children with Down syndrome. (Contains references.) (Author/CR)

The appropriateness of the Aberrant Behavior Checklist (ABC) was investigated with 199 youngsters with dual diagnosis of mental retardation and psychiatric disturbance. With some cautions, the ABC is recommended, based on the robustness of its factor structure, clinically meaningfulness of the subscale scores, and internal consistency of the…

This article reports on the outcomes of a study that used functional communication training (FCT) with two students, (ages 6 and 15) with autism and severe mental retardation, to add information to a database assessing the potential generalized effects of FCT and to examine the role that contingencies for appropriate and problem behaviors play in…

This study examined the validity and internal and interrater reliability of the Wing Subgroups Questionnaire, an assessment that classifies children with autism into subtypes. Subjects were 42 students (ages 5 to 22) enrolled in multihandicapped special education classrooms. Findings support the reliability and validity of the questionnaire for…

Thirteen children (ages 5-11) with autism and symptoms of attention-deficit hyperactivity disorder participated in a double-blind, placebo-controlled crossover study of methylphenidate. Eight subjects responded positively, decreasing their hyperactivity. Ratings of stereotypy and inappropriate speech also decreased, however, no changes were found…

A study of 211 children and adults with autism (n=81), other pervasive development disorders (PDD) (n=24), and conditions other than PDD (n=106) found the prevalence of medical conditions with suspected etiologic relationships with autism varies between 10 and 15%, depending on the diagnostic system employed. (Author/CR)