This study investigated the feasibility and effectiveness of using a flipped classroom (FC) approach to combine self-regulated learning (SRL) instruction and out-of-class eLearning activities in a two-year reading intervention program to facilitate students' learning of classical Chinese reading. A total of 352 junior secondary students from three Hong Kong secondary schools participated in the study voluntarily. Using a quasi-experimental design, students from each school were assigned to one of the following conditions: SRL instruction plus out-of-class eLearning (EG-I+E), SRL instruction only (EG-I), and control (CG). Both quantitative methods, including reading tests and student questionnaires, and qualitative methods, including teacher and student interviews, were adopted to collect data for the program evaluation. Findings indicate that after implementing the intervention program, EG students perceived significant changes in their classical Chinese lessons to be more SRL-oriented. While all treatment groups significantly improved their performance in the reading post-tests, only EG students significantly improved their strategy use, self-efficacy, and intrinsic motivation. Although both EG groups had similar improvements in all outcome measures, teachers and students of EG-I+E opined that the eLearning component of FC facilitated teachers' implementation of the intervention and students' strategy learning and motivation. Findings are discussed to shed light on applying SRL instruction and FC in a school subject long dominated by teacher-centered instruction.