This study explores university students' perceptions of how the classroom learning environment and Economics teachers' instructional practices promote learning in higher education (HE). The purpose of the study was to develop and empirically test a framework that characterises quality Economics instruction. Based on a literature review, a conceptual framework was built consisting of 75 attributes related to quality teaching and learning of Economics. To test the validity of the framework, a cross-sectional survey design was adopted to collect the data on students' evaluation of teachers' effectiveness in promoting students learning. The study respondents comprise 403 students sampled from four public universities in Ghana. Exploratory and confirmatory factor analysis suggests that the conceptual framework is valid and reliable and can effectively be used to evaluate quality Economics instruction in higher education. The results indicate key areas that are beneficial concerning student perceptions of teacher effectiveness in promoting student learning. These include planning and preparation, scaffolding of instruction, classroom communication, classroom management, classroom learning environment, and teacher characteristics. We argue that these factors are significant predictors of quality Economics instruction in HE and suggest a model that can be used as an effective evaluation tool or training toolkit for ensuring high-quality teaching involving Economics. HE authorities need to constantly evaluate Economics teaching in the key domain areas based on students' feedback to improve upon quality teaching and learning.