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Developmental Alterations of Frontal-Striatal-Thalamic Connectivity in Obsessive-Compulsive Disorder
Peer reviewed
Direct linkFitzgerald, Kate Dimond; Welsh, Robert C.; Stern, Emily R.; Angstadt, Mike; Hanna, Gregory L.; Abelson, James L.; Taylor, Stephan F. – Journal of the American Academy of Child & Adolescent Psychiatry, 2011
Objective: Pediatric obsessive-compulsive disorder is characterized by abnormalities of frontal-striatal-thalamic circuitry that appear near illness onset and persist over its course. Distinct frontal-striatal-thalamic loops through cortical centers for cognitive control (anterior cingulate cortex) and emotion processing (ventral medial frontal…
Descriptors: Cognitive Ability, Brain Hemisphere Functions, Behavior Disorders, Comparative Analysis
Dumontheil, Iroise; Burgess, Paul W.; Blakemore, Sarah-Jayne – Developmental Medicine & Child Neurology, 2008
Information on the development and functions of rostral prefrontal cortex (PFC), or Brodmann area 10, has been gathered from different fields, from anatomical development to functional neuroimaging in adults, and put forward in relation to three particular cognitive and behavioural disorders. Rostral PFC is larger and has a lower cell density in…
Descriptors: Schizophrenia, Etiology, Brain Hemisphere Functions, Brain
