Emotion dysregulation is common in autism spectrum disorder; a better understanding of the underlying neural mechanisms could inform treatment development. The tendency toward repetitive cognition in autism spectrum disorder may also increase susceptibility to perseverate on distressing stimuli, which may then increase emotion dysregulation.…

Diffusion tensor imaging studies show white matter (WM) abnormalities in children with autism spectrum disorder (ASD). However, investigations are often limited by small samples, particularly problematic given the heterogeneity of ASD. We explored WM using DTI in a large sample of 130 children and adolescents (7-15 years) with and without ASD,…

Stimulus over-selectivity refers to behavior being controlled by one element of the environment at the expense of other equally salient aspects of the environment. This is a common problem for many individuals, including those with autism spectrum disorders, and learning difficulties, and presents a considerable problem for information processing…

Previous studies by our group suggest that the neuropathology of autism is characterized by a disturbance of cortical modularity. In this model a decrease in the peripheral neuropil space of affected minicolumns provides for an inhibitory deficit and a readjustment in their signal to noise bias during information processing. In this study we…

A critical review of the literature indicates that overselective attention: (1) is not limited to autistic children, (2) may be only one of several developmental lags these children display, and (3) may or may not be strongly correlated with children's language abilities and general intellectual abilities. (Author)

Interest regarding neural information processing in autism is growing because atypical perceptual abilities are a characteristic feature of persons with autism. Central to our review is how characteristic perceptual abilities, referred to as "perceptual signatures," can be used to suggest a neural etiology that is specific to autism. We review…

Based on the hypothesis that cognition and sleep are linked, this study compared the sleep patterns of nine children (ages 6-16) with autism with those of children with mental retardation and no disabilities. The children with autism were observed for two consecutive nights at a laboratory where their sleep patterns were recorded. Results found…