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Junxi Zou; Xiaoyu Wang; Xuan Liu; Yuan Zheng; Wei Shao; Qing-Wei Zhang; Pingping Zhu; Lingling Li – Journal of Chemical Education, 2024
The crystalline sponge method allows for direct and precise molecular structure determination of liquid and gaseous targets and thus has been recognized as a revolutionary breakthrough in crystallography. To expose undergraduates to this cutting-edge technique, we have developed a comprehensive laboratory experiment with reaction conditions and…
Descriptors: Undergraduate Study, College Science, Laboratory Experiments, Molecular Structure
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Audrey G. Fikes; Melissa C. Srougi – Journal of Chemical Education, 2023
The application of chemistry concepts in biological settings plays an important role in the interdisciplinary field of drug discovery and development. This is true for molecular docking, where an understanding of intermolecular forces and noncovalent interactions is useful for rational drug design and development. Here we report the design and use…
Descriptors: Chemistry, Science Instruction, Molecular Structure, Drug Therapy
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Soule`re, Laurent – Journal of Chemical Education, 2021
We report a molecular modeling study for undergraduate students aimed at carrying out an analysis of small molecules using a systematic conformational search with VEGA ZZ, a freely available software program. Conformational analyses were performed using a systematic search based on variations of torsion angles. First, the conformations of n-butane…
Descriptors: Computer Assisted Instruction, Computer Software, Open Source Technology, Undergraduate Students
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Dias, Lucas A. L.; Faria, Roberto B. – Journal of Chemical Education, 2020
The use of symmetry is widespread in chemistry, as it is used for predictions of the number of allowed and forbidden absorptions in electronic, vibrational, and rotational spectroscopies; for predictions of the combination of atomic orbitals to produce molecular orbitals; and in many other chemical applications. One critical step in these…
Descriptors: Science Instruction, Molecular Structure, Computer Software, Educational Technology
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Romero, Rebecca M.; Bolger, Michael B.; Morningstar-Kywi, Noam; Haworth, Ian S. – Journal of Chemical Education, 2020
Drug design and development requires collaboration among scientists with diverse expertise. In early-stage drug design, establishment of promising drug candidates requires integration of structure-based molecular design with biopharmaceutics and ADMET (absorption, distribution, metabolism, excretion, and toxicity) principles. Much of this work is…
Descriptors: Computer Software, Educational Technology, Technology Uses in Education, Pharmacology
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Lucas, Krista L. – Science Activities: Projects and Curriculum Ideas in STEM Classrooms, 2021
Molecular processes are highly complex, and are frequently difficult for high school and college students to comprehend. Because of the importance of visualization in learning, along with formative assessment of student understanding, utilization of 3D modeling software aids both educators and students alike. The activity described below required…
Descriptors: Molecular Biology, Science Instruction, Teaching Methods, Scientific Concepts
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Lohning, Anna E.; Hall, Susan; Dukie, Shailandra – Journal of Chemical Education, 2019
Students often approach biochemistry with a degree of trepidation with many considering it one of the more difficult subjects. This is, in part, due to the necessity of making visual images of submicroscopic concepts. Molecular interactions underpin most biological processes; therefore, mastering these concepts is essential. Understanding the…
Descriptors: Undergraduate Students, College Science, Biochemistry, Computer Peripherals
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Tavares, Maurício T.; Primi, Marina C.; Silva, Nuno A. T. F.; Carvalho, Camila F.; Cunha, Micael R.; Parise-Filho, Roberto – Journal of Chemical Education, 2017
Teaching the molecular aspects of drug-target interactions and selectivity is not always an easy task. In this context, the use of alternative and engaging approaches could help pharmacy and chemistry students better understand this important topic of medicinal chemistry. Herein a 4 h practical exercise that uses freely available software as a…
Descriptors: Science Instruction, Teaching Methods, Pharmacology, College Science
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Behmke, Derek; Kerven, David; Lutz, Robert; Paredes, Julia; Pennington, Richard; Brannock, Evelyn; Deiters, Michael; Rose, John; Stevens, Kevin – Proceedings of the Interdisciplinary STEM Teaching and Learning Conference, 2018
Spatial reasoning is defined as the ability to generate, retain, and manipulate abstract visual images. In chemistry, spatial reasoning skills are typically taught using 2-D paper-based models, 3-D handheld models, and computerized models. These models are designed to aid student learning by integrating information from the macroscopic,…
Descriptors: Science Instruction, Computer Simulation, Educational Technology, Molecular Structure
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Robertson, Michael J.; Jorgensen, William L. – Journal of Chemical Education, 2015
Orbital theory provides a powerful tool for rationalizing and understanding many phenomena in chemistry. In most introductory chemistry courses, students are introduced to atomic and molecular orbitals in the form of two-dimensional drawings. In this work, we describe a general method for producing 3D printing files of orbital models that can be…
Descriptors: Organic Chemistry, Visual Aids, Theories, Molecular Structure
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Litofsky, Joshua; Viswanathan, Rama – Journal of Chemical Education, 2015
Matrix diagonalization, the key technique at the heart of modern computational chemistry for the numerical solution of the Schrödinger equation, can be easily introduced in the physical chemistry curriculum in a pedagogical context using simple Hückel molecular orbital theory for p bonding in molecules. We present details and results of…
Descriptors: Science Instruction, Chemistry, Equations (Mathematics), Teaching Methods
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Sohlberg, Karl; Liu, Xiang – Journal of Chemical Education, 2013
Herein, a slightly enhanced version of extended Huckel molecular orbital theory is applied to demonstrate the spontaneous distortion of 1,3,5,7-cyclooctatetraene from a perfect octagon, a consequence of the Jahn-Teller effect. The exercise is accessible to students who have been introduced to basic quantum mechanics and extended Huckel molecular…
Descriptors: Science Instruction, College Science, Chemistry, Molecular Structure
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Martini, Sheridan R.; Hartzell, Cynthia J. – Journal of Chemical Education, 2015
Computational chemistry is commonly addressed in the quantum mechanics course of undergraduate physical chemistry curricula. Since quantum mechanics traditionally follows the thermodynamics course, there is a lack of curricula relating computational chemistry to thermodynamics. A method integrating molecular modeling software into a semester long…
Descriptors: Science Instruction, Chemistry, Quantum Mechanics, College Science
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Nagaoka, Shin-ichi; Teramae, Hiroyuki; Nagashima, Umpei – Journal of Chemical Education, 2013
At an early stage of learning quantum chemistry, undergraduate students usually encounter the concepts of the particle in a box, the harmonic oscillator, and then the particle on a sphere. Rotational levels of a diatomic molecule can be well approximated by the energy levels of the particle on a sphere. Wave functions for the particle in a…
Descriptors: Science Instruction, Chemistry, College Science, Molecular Structure
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Ochterski, Joseph W. – Journal of Chemical Education, 2014
This article describes the results of using state-of-the-art, research-quality software as a learning tool in a general chemistry secondary school classroom setting. I present three activities designed to introduce fundamental chemical concepts regarding molecular shape and atomic orbitals to students with little background in chemistry, such as…
Descriptors: Science Instruction, Chemistry, Computer Software, Computer Uses in Education
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