Raman scattering is a powerful tool for revealing the vibrations of molecules, but as a nonlinear optical phenomenon, its signals can change via mechanisms like resonance enhancement that have no direct analogue in infrared spectroscopy. In this work, complementary measurements conducted on 4-nitrophenol and its conjugate base allow students to…

A two to three period analytical chemistry experiment has been developed which allows second year students to explore chemical color tests used to detect adulterated pharmaceuticals. Students prepare several paper analytical devices (PADs) to generate positive and negative controls antibiotics, along with cutting agents such as starch and chalk.…

Given the growing prevalence of computational methods in chemistry, it is essential that undergraduate curricula introduce students to these approaches. One such area is the application of machine learning (ML) techniques to chemistry. Here we describe a new activity that applies ML regression analysis to the common physical chemistry laboratory…

The identification of coloring substances is a relevant task in the field of conservation and restoration, but it can be challenging as in real samples the target analytes are inserted in a very complex matrix made of binders and additives. Understanding this concept is fundamental for upper-division undergraduate students interested in…

Student feedback from an undergraduate biochemistry lab course suggested the use of visibly traceable proteins may assist learning. Based on this feedback, we used guided inquiry lab exercises where students developed and characterized a suite of fluorescent protein-dihydrofolate reductase (DHFR) fusions as tools for a biochemistry teaching lab.…

Ever since Newton's groundbreaking work on the composed nature of light, additive colour mixing (and its laws) are subject to the interest of physicists as well as other sciences. In this paper, we present a setup for simple lab or home experiments on additive colour mixing and the laws of colour mixing. Students use the screen of a laptop or…

We have developed a multivariate and multidisciplinary lab experiment on the synthesis of alginate hydrogel beads of various sizes and dye encapsulation for upper-division undergraduate and graduate students. This experiment introduces students to several common concepts in polymer chemistry, materials science, and drug delivery. The experiment…

Mobile phones are a widely used platform for educational apps, mobile health, and a variety of chemical tests. Here, we are working on a mobile phone-based physics lab (mPhysics) that uses a mobile phone's capabilities to run simple physics experiments and demonstrations. While a mobile phone can be used to analyze magnetic and optical properties…

Gas emission tubes are widely used laboratory and demonstration apparatus because the line source nature of the tube produces line spectra when viewed directly through a diffraction grating. These are long and distinctly visible images of the tube, located to either side of the zeroth order at an angle determined by the wavelength. A continuous…

We describe a paper-based microfluidic device for iron(III) assay in an applied instrumental analysis laboratory. Simple and convenient devices were fabricated by the students using patterning of filter paper to investigate three different procedures: drawing a boundary with eyeliner or wax pen; drawing a boundary with waterproof permanent marker…

Laboratory experiments provide students a tangible means of understanding dry, abstract concepts. A simple and engaging introductory wet chemistry laboratory has been developed relating quantum mechanics to color, which has been implemented for a class of about 600 students per academic year for over three years at Brown University. Color is an…

Candy, an everyday treat, is a convenient theme for teaching chemistry. Making candy incorporates solution concentration, colligative properties, and phase transformations while flavoring and color reflect synthesis or extraction. In this article, a nonscience major laboratory course on candy chemistry is presented. The course combines laboratory…

A low-cost turbidimeter, colorimeter, and nephelometer (TCN) multipurpose instrument applicable for undergraduate, graduate, and research laboratories is demonstrated within this work. The instrument relies on simple and robust electronics while using a PC sound card as an analog-to-digital converter. The performance of the instrument was…

Unlike the large number of laboratory experiments on phase-transfer catalysis (PTC) that focus on a catalyzed chemical process, the present laboratory emphasizes the mechanism of phase transfer catalysis itself. Students can follow visually the actual transfer of the reagent by the catalyst, and its consumption in the organic phase, in a…

Generating enthusiasm among nonscience majors in a laboratory course is a difficult task. Often, students are asked to perform a precipitation reaction, only to collect and then safely dispose of the solid without detailing composition, properties, or uses. In an effort to keep the students engaged, this laboratory exercise presents an innovative…