Outcome measures for students enrolled in separate sections of a manual communication course taught by the same instructor were compared. One group received instruction in a traditional university classroom setting. The other group received instruction through asynchronous, videostreamed online delivery. No statistically significant differences in expressive manual communication skills, as well as content knowledge, were found. There was a significant difference in the receptive comprehension of manually communicated information, even though the difference was only 6%. Results are discussed in terms of potential for online instruction to aid in addressing the critical shortage of personnel needed to provide services for students who are deaf and hard of hearing.